2-[(1H-Indol-2-yl)methyl]piperazine | 218594-54-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[(1H-Indol-2-yl)methyl]piperazine
• 英文别名: 2-(piperazin-2-ylmethyl)-1H-indole
• CAS: 218594-54-8
• 化学式: C₁₃H₁₇N₃
• 分子量: 215.298
• InChiKey: ZOWMTYKIOFIWJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  39.8
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• N-triazolymethyl-piperazine compounds with neurokinin-receptor antagonist activity
  申请人：——

  公开号：US20020065276A1

  公开（公告）日：2002-05-30

  N-triazolylmethyl-piperazine compounds which exhibit neurokinin receptor antagonistic activity corresponding to the formula I: 1 wherein R 1 , R 2 and R 3 have the meanings given in the specification; pharmaceutical compositions containing these compounds; a process for preparing these compounds, and intermediate products of this process.

  N-三唑甲基-哌嗪化合物表现出与公式I对应的神经激肽受体拮抗活性： 1 其中 R 1 ，R 2 和R 3 具有规范中给定的含义；含有这些化合物的药物组合物；制备这些化合物的方法，以及该过程的中间产物。
• AROYL-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TACHYKININ ANTAGONISTS
  申请人：——

  公开号：US20030114668A1

  公开（公告）日：2003-06-19

  This invention relates to piperazine derivatives of formula (I), wherein Y is bond or lower alkylene, R1 is aryl which may have substituent(s), R2 is aryl or indolyl, each of which may have substituent(s), R3 is hydrogen or lower alkyl, and R4 is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human beings or animals. 1

  本发明涉及式(I)的哌嗪衍生物，其中Y是键或低级烷基，R1是可能含有取代基的芳基，R2是芳基或吲哚基，其中每个都可能含有取代基，R3是氢或低级烷基，R4如描述中定义，以及其药用可接受的盐，其制备过程，包含该化合物的药物组合物，以及用于治疗或预防人类或动物中速激肽介导的疾病的用途。
• [EN] SUBSTITUTED INDOLE LIGANDS FOR THE ORL-1 RECEPTOR<br/>[FR] LIGANDS D'INDOLE SUBSTITUES DESTINES UN RECEPTEUR ORL-1
  申请人：GLAXOSMITHKLINE SPA

  公开号：WO2005005411A1

  公开（公告）日：2005-01-20

  New ligands for the ORL-1 receptor are described, useful for modulating the activity of said receptors in a patient in need thereof, and for preventing and treating illnesses dependent on the stimulation of this receptor. The new compounds conform to structural formula (I), wherein Q is a moiety of formula (II) and R, R0, R1, R2, R3, R4, R5, R6 are further defined in the description.

  描述了用于调节ORL-1受体活性的新配体，适用于需要此类受体的患者，并用于预防和治疗依赖于该受体刺激的疾病。这些新化合物符合结构式（I），其中Q是式（II）的一个部分，而R、R0、R1、R2、R3、R4、R5、R6在描述中进一步定义。
• Substituted indole ligands for the ORL-1 receptor
  申请人：NIKEM RESEARCH S.R.L.

  公开号：EP1676843A1

  公开（公告）日：2006-07-05

  New ligands for the ORL-1 receptor are described, useful for modulating the activity of said receptors in a patient in need thereof, and for preventing and treating illnesses dependent on the stimulation of this receptor. The new compounds conform to structural formula (I) wherein R1, R2, R3, R4 are further defined in the description.

  本文介绍了ORL-1受体的新配体，可用于调节需要该受体活性的患者的活性，并预防和治疗依赖于该受体刺激的疾病。新化合物符合结构式（I），其中R1、R2、R3、R4在描述中进一步定义。
• Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists
  申请人：Miyake Hiroshi

  公开号：US20050027121A1

  公开（公告）日：2005-02-03

  This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

  本发明涉及以下式子的哌嗪衍生物：其中每个符号如描述中定义的那样，并且其药学上可接受的盐，用于其制备的过程，包括相同的制药组合物，以及用于治疗或预防人类或动物的Tachykinin介导疾病的用途。