agomelatine hydrobromide | 1176317-02-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: agomelatine hydrobromide
• 英文别名: N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide;hydrobromide
• CAS: 1176317-02-4
• 化学式: BrH*C₁₅H₁₇NO₂
• 分子量: 324.217
• InChiKey: QZZUBTCVSXILLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  38.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  阿戈美拉汀 在 氢溴酸 作用下， 以 乙酸乙酯 为溶剂， 生成 agomelatine hydrobromide
  参考文献：
  名称：

  AGOMELATINE HYDROHALIDE COMPLEX AND PREPARATION METHOD THEREOF

  摘要：

  本发明涉及阿戈美拉汀的复合物及其制备。通过本方法获得的阿戈美拉汀的氢卤酸盐复合物比阿戈美拉汀本身更溶解、更稳定、更纯净，更适合用于制药准备。使用这种方法，可以通过简单的过程获得高纯度的产品，而无需进行进一步复杂的步骤。

  公开号：

  US20110313198A1

文献信息

• [EN] AGOMELATINE HYDROBROMIDE HYDRATE AND PREPARATION THEREOF<br/>[FR] BROMHYDRATE D'AGOMÉLATINE HYDRATÉ ET SA PRÉPARATION
  申请人：SERVIER LAB

  公开号：WO2011113363A1

  公开（公告）日：2011-09-22

  An agomelatine hydrobromide hydrate of formula (I), in which X is Br, preparation method and use thereof as well as pharmaceutical composition containing it are provided. The solubility of the agomelatine hydrobromide hydrate obtained by the present method is significantly higher than that of agomelatine. Therefore, it is more suitable for manufacturing pharmaceutical formulations. In addition, the product has higher stability and purity. The present product of high purity can be obtained through a simple process, rather than process with complicated steps.

  本发明提供了一种化学式为（I）的阿戈美拉汀氢溴酸盐水合物，其中X为Br，以及其制备方法和用途，以及包含它的制药组合物。本方法所得到的阿戈美拉汀氢溴酸盐水合物的溶解度显著高于阿戈美拉汀。因此，它更适合制造制药配方。此外，该产品具有更高的稳定性和纯度。高纯度的本产品可以通过简单的过程获得，而不是复杂的步骤。
• CRYSTAL FORM VII OF AGOMELATINE, PREPARATION METHOD AND USE THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
  申请人：Huang Yu

  公开号：US20140011883A1

  公开（公告）日：2014-01-09

  The present invention provides a new crystalline form VII of agomelatine, its method of preparation, application and pharmaceutical composition. This new crystalline form offers high purity, a stable crystalline structure and good reproducibility, while its method of production lends itself well to large scale production. In terms of stability and purity, it is superior to the numerous crystalline forms which have hitherto been reported. As a result, the crystalline form VII of the present invention possesses advantages in pharmaceutical preparation.

  本发明提供了一种新的阿戈美拉汀七号晶体形态，其制备方法、应用和制药组合物。这种新的晶体形态具有高纯度、稳定的晶体结构和良好的再现性，而其生产方法适合大规模生产。在稳定性和纯度方面，它优于迄今报道的众多晶体形态。因此，本发明的七号晶体形态在制药制备方面具有优势。
• AGOMELATINE HYDROBROMIDE HYDRATE AND PREPARATION THEREOF
  申请人：Shan Hanbin

  公开号：US20130012592A1

  公开（公告）日：2013-01-10

  The present invention relates to an agomelatine hydrobromide hydrate of formula I wherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrobromide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps.

  本发明涉及公式I的阿戈美拉汀氢溴酸盐水合物，其中X为Br，以及其制备和使用，以及含有它的制药组合物。通过本方法获得的阿戈美拉汀氢溴酸盐水合物的溶解度显著提高，比阿戈美拉汀更适合制造制药配方。此外，该产品具有更高的稳定性和纯度。使用本方法，可以通过简单的过程获得高纯度的产品，而不需要任何复杂的步骤。
• NEW CRYSTAL FORM VII OF AGOMELATINE, PREPARATION METHOD AND USE THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
  申请人：Les Laboratoires Servier

  公开号：EP2690087B1

  公开（公告）日：2017-08-30