| 1392207-02-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• CAS: 1392207-02-1
• 化学式: C₂₆H₃₀N₂O₆
• 分子量: 466.534
• InChiKey: JZOKRMQHSDOFJT-BSWISCRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  34.0
• 可旋转键数：
  6.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  87.19
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  奎宁 、 5-chlorocarboxy-5-methyl-1,3-dioxan-2-one 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以0.39 g的产率得到
  参考文献：
  名称：

  Organocatalytic Synthesis of Quinine-Functionalized Poly(carbonate)s

  摘要：

  The ring-opening polymerization of substituted cyclic carbonates with 1-(3,5-bis-trifluoromethyl-phenyl)-3-cyclohexyl-thiourea (TU)/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) organocatalysts afford highly functionalized oligocarbonates. The fluorescent alkaloid quinine can be readily incorporated into the oligocarbonates either by initiation from quinine or by ring-opening polymerization of a quinine-functionalized cyclic carbonate (MTC-Q). Copolymerization of MTC-Q with a boc-protected guanidinium cyclic carbonate affords, after deprotection, highly water-soluble cationic copolymers functionalized with both quinine and pendant guanidinium groups. When multiple quinine groups are attached to the oligomers, they exhibit minimal fluorescence due to self quenching Upon hydrolysis, the fluorescence intensity increases, providing a potential strategy for monitoring the hydrolysis rates in real time.

  DOI：

  10.1021/bm300718b