缬氨酰组氨酰亮氨酰苏氨酰脯氨酸 | 93913-38-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 缬氨酰组氨酰亮氨酰苏氨酰脯氨酸
• 英文名称: Valylhistidylleucylthreonylproline
• 英文别名: 1-[2-[[2-[[2-[(2-amino-3-methylbutanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carboxylic acid
• CAS: 93913-38-3
• 化学式: C₂₆H₄₃N₇O₇
• 分子量: 565.7
• InChiKey: BYCSDJAWFOZAFO-UHFFFAOYSA-N

物化性质

• 沸点：
  1003.2±65.0 °C(Predicted)
• 密度：
  1.281±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  40
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  220
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• REAGENT CONTAINING PROTEASE REACTION PROMOTER AND/OR COLORANT STABILIZER
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP1788081A1

  公开（公告）日：2007-05-23

  [PROBLEMS] To provide a protease reaction promoter being superior in usefulness to the known protease reaction promoters, a stabilizer for a colorant to be used in detecting an enzymatic reaction, a method therefor and a reagent and a method for measuring a glycosylated protein and the ratio of a glycosylated protein with the use of the same. [MEANS FOR SOLVING PROBLEMS] A protease reaction promoter which contains at least one member selected from among an acetate group-containing compound or its salt, N-acyltaurine or its salt and a polyoxyethylene alkyl ether sulfate or its salt; a method of promoting a protease reaction by using this protease reaction promoter, a stabilizer reagent containing cyclodextrin for stabilizing a colorant to be used in detecting an enzymatic reaction; a method of stabilization via the coexistence of cyclodextrin with the above colorant; and a reagent and a method for measuring a glycosylated protein and the ratio of a glycosylated protein with the use of the protease reaction promoter and/or the reagent containing cyclodextrin as described above.

  [问题] 提供一种在实用性上优于已知蛋白酶反应促进剂的蛋白酶反应促进剂、一种用于检测酶反应的着色剂的稳定剂、一种用于此的方法以及一种使用该促进剂和稳定剂测量糖基化蛋白质和糖基化蛋白质比率的试剂和方法。[解决问题的方法]一种蛋白酶反应促进剂，它含有至少一种选自含醋酸基的化合物或其盐、N-酰基牛磺酸或其盐和聚氧乙烯烷基醚硫酸盐或其盐中的成员；一种通过使用这种蛋白酶反应促进剂促进蛋白酶反应的方法，一种含有环糊精的稳定剂试剂，用于稳定检测酶反应中使用的着色剂；通过环糊精与上述着色剂共存进行稳定的方法；以及使用上述蛋白酶反应促进剂和/或含有环糊精的试剂测量糖基化蛋白质和糖基化蛋白质比率的试剂和方法。
• Reagent Containing Protease Reaction Promoter and/or Colorant Stabilizer
  申请人：Kouzuma Takuji

  公开号：US20070224685A1

  公开（公告）日：2007-09-27

  Provided are: a protease reaction promoter which is superior in usefulness to the known protease reaction promoters; a stabilizer for a colorant used for detection of an enzymatic reaction, and a method of stabilizing the colorant; and a reagent for and a method of measuring a glycated protein and a ratio of a glycated protein using the same. There are provided: a protease reaction promoter which contains at least one kind selected from the group consisting of an acetate group-containing compound or a salt thereof, N-acyl taurine or a salt thereof, and a polyoxyethylene alkyl ether sulfuric acid or a salt thereof; a method of promoting a protease reaction by using the protease reaction promoter; a stabilizer reagent for stabilizing a colorant used for detection of an enzymatic reaction, which contains a cyclodextrin; a stabilization method, including allowing a cyclodextrin to coexist with the colorant; and a reagent for and a method of measuring a glycated protein and a ratio of a glycated protein by using the protease reaction promoter and/or the reagent containing a cyclodextrin.