N-hydroxy-2-(4-(4-(1-methyl-1H-indol-5-yl)butyl)phenyl)acetamide | 1579293-93-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-hydroxy-2-(4-(4-(1-methyl-1H-indol-5-yl)butyl)phenyl)acetamide
• 英文别名: N-hydroxy-2-[4-[4-(1-methylindol-5-yl)butyl]phenyl]acetamide
• CAS: 1579293-93-8
• 化学式: C₂₁H₂₄N₂O₂
• 分子量: 336.434
• InChiKey: ZKXSFVIRLJXLTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  54.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Histone Deacetylase Inhibitors for Enhancing Activity of Antifungal Agents
  申请人：METHYLGENE INC.

  公开号：US20140081017A1

  公开（公告）日：2014-03-20

  The present invention relates to compositions and methods to selectively treat fungal infection. More particularly, the invention relates to compounds, compositions thereof, and methods for selectively enhancing fungal sensitivity to antifungal compounds. The compositions of the invention are comprised of a combination of a histone deacetylase inhibitor, or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, agricultural formulation, prodrug or complex thereof, and an antifungal agent, the histone deacetylase inhibitor being a compound of Formula (I):

  本发明涉及用于选择性治疗真菌感染的组合物和方法。更具体地，本发明涉及化合物、其组合物以及用于增强真菌对抗真菌化合物敏感性的方法。本发明的组合物由组成，其中组脱乙酰酶抑制剂的组合物，或N-氧化物、水合物、溶剂化合物、药用可接受盐、农药配方、前药或其复合物，以及抗真菌剂，其中组脱乙酰酶抑制剂为式(I)的化合物：
• [EN] HISTONE DEACETYLASE INHIBITORS FOR ENHANCING ACTIVITY OF ANTIFUNGAL AGENTS<br/>[FR] INHIBITEURS D'HISTONE DÉSACÉTYLASE POUR L'ACCROISSEMENT DE L'ACTIVITÉ D'AGENTS ANTIFONGIQUES
  申请人：METHYLGENE INC

  公开号：WO2014041424A1

  公开（公告）日：2014-03-20

  The present invention relates to compositions and methods to selectively treat fungal infection. More particularly, the invention relates to compounds, compositions thereof, and methods for selectively enhancing fungal sensitivity to antifungal compounds. The compositions of the invention are comprised of a combination of a histone deacetylase inhibitor, or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, agricultural formulation, prodrug or complex thereof, and an antifungal agent, the histone deacetylase inhibitor being a compound of Formula (I).