3-benzo[1,3]dioxol-5-yl-5-[4-(2-fluoroethoxy)phenyl]-5-hydroxy-4-(3,4,5-trimethoxybenzyl)-5H-furan-2-one | 1196878-65-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 3-benzo[1,3]dioxol-5-yl-5-[4-(2-fluoroethoxy)phenyl]-5-hydroxy-4-(3,4,5-trimethoxybenzyl)-5H-furan-2-one
• 英文别名: 3-(1,3-benzodioxol-5-yl)-5-[4-(2-fluoroethoxy)phenyl]-5-hydroxy-4-[(3,4,5-trimethoxyphenyl)methyl]furan-2-one
• CAS: 1196878-65-5
• 化学式: C₂₉H₂₇FO₉
• 分子量: 538.526
• InChiKey: UOCWQSCYEUUPBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  3,4,5-三甲氧基苯甲醛 、 2-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-4-oxobutyric acid methyl ester 在 sodium methylate 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 17.0h， 以29%的产率得到3-benzo[1,3]dioxol-5-yl-5-[4-(2-fluoroethoxy)phenyl]-5-hydroxy-4-(3,4,5-trimethoxybenzyl)-5H-furan-2-one
  参考文献：
  名称：

  PET-compatible endothelin receptor radioligands: Synthesis and first in vitro and in vivo studies

  摘要：

  The expression and function of endothelin (ET) receptors is abnormal in cardiovascular diseases, tumor progression, and tumor metastasis. In this study, we prepared two [F-18]-fluorinated derivatives of the non-peptide ETA receptor antagonist PD 156707 and evaluated their ET receptor binding potencies. Ex vivo as well as in vivo biodistribution studies in mice were performed, as well as the metabolism of the radiotracer, which was examined by metabolite analysis in mice and rats. All tested derivatives of PD 156707 exhibited potent in vitro pharmacological characteristics with K-i values comparable to that of the lead compound. The biodistribution studies showed a high accumulation of the tracer in bile and intestine. In vivo we were able to show that the visualization of the heart as a major target organ with high ETAR expression is possible. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.08.058