L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester | 871927-89-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester
• CAS: 871927-89-8
• 化学式: C₂₈H₃₃N₃O₁₀
• 分子量: 571.584
• InChiKey: XUIKINAZRZZQID-FKBYEOEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.29
• 重原子数：
  41.0
• 可旋转键数：
  15.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  189.42
• 氢给体数：
  3.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester 在 lithium hydroxide 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 16.0h， 生成 (2S)-2-[[(2S)-3-carboxy-2-[[(2S)-3-carboxy-2-[6-[3-[2-[2-(2-phenylethynyl)cyclohexen-1-yl]ethynyl]phenyl]hex-5-ynoylamino]propanoyl]amino]propanoyl]amino]butanedioic acid
  参考文献：
  名称：

  Synthesis and Protein Degradation Capacity of Photoactivated Enediynes

  摘要：

  The viability of proteins as targets of thermally and photoactivated enediynes has been confirmed at the molecular level. Model studies using a labeled substrate confirmed the efficacy of atom transfer from diyl radicals produced from enediynes to form captodatively stabilized carbon centered aminoacyl radicals, which then undergo either fragmentation or dimerization. To exploit this finding, a family of enediynes was developed using an intramolecular coupling strategy. Derivatives were prepared and used to target specific proteins, showing good correlation between affinity and photoinduced protein degrading activity. The findings have potential applications in the design of artificial chemical proteases and add to our understanding of the mechanism of action of the clinically important enediyne antitumor antibiotics.

  DOI：

  10.1021/jo051403q
• 作为产物：
  描述：

  α-L-aspartyl β-benzyl ester L-aspartic acid dimethyl ester 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三甲基硅咪唑 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 15.11h， 生成 L-2-[2-(2-amino-3-benzyloxycarbonyl-propionylamino)-3-benzyloxycarbonyl-propionylamino]-succinic acid dimethyl ester
  参考文献：
  名称：

  Synthesis and Protein Degradation Capacity of Photoactivated Enediynes

  摘要：

  The viability of proteins as targets of thermally and photoactivated enediynes has been confirmed at the molecular level. Model studies using a labeled substrate confirmed the efficacy of atom transfer from diyl radicals produced from enediynes to form captodatively stabilized carbon centered aminoacyl radicals, which then undergo either fragmentation or dimerization. To exploit this finding, a family of enediynes was developed using an intramolecular coupling strategy. Derivatives were prepared and used to target specific proteins, showing good correlation between affinity and photoinduced protein degrading activity. The findings have potential applications in the design of artificial chemical proteases and add to our understanding of the mechanism of action of the clinically important enediyne antitumor antibiotics.

  DOI：

  10.1021/jo051403q