α-Benzyloxycarbonylamino-acetessigsaeuremethylester | 156571-70-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α-Benzyloxycarbonylamino-acetessigsaeuremethylester
• 英文别名: Methyl 3-oxo-2-[[(phenylmethoxy)carbonyl]amino]butanoate；methyl 3-oxo-2-(phenylmethoxycarbonylamino)butanoate
• CAS: 156571-70-9
• 化学式: C₁₃H₁₅NO₅
• 分子量: 265.266
• InChiKey: YPQTYRXAIUQSST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  α-Benzyloxycarbonylamino-acetessigsaeuremethylester 在 palladium on activated charcoal calcium sulfate 、 molecular sieve 、 Amberlyst-15 (H+) 、 氢气 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 24.0h， 生成 methyl 3,3-diethoxy-2-<(1H-indol-2-yl)methylene>aminobutyrate
  参考文献：
  名称：

  A new efficient synthesis of ethyl β-carboline-3-carboxylate (β-CCE) and methyl 4-methyl-β-carboline-3-carboxylate (4-methyl-β-CCM) starting fr

  摘要：

  Ethyl beta-carboline-3-carboxylate (9) and methyl 4-methyl-beta-carboline-3-carboxylate (15) were prepared in high yields hy condensing indole-2-carboxaldehyde (5) (itself prepared by lithium aluminum hydride reduction of the Weinreb amide derived from indole-2-carboxylic acid) with ethyl 2-amino-3,3-diethoxypropionate (6) and methyl 2-amino-3,3-diethoxybutyrate (12), respectively, followed by reduction of the imine bonds formed with sodium cyanoborohydride and cyclization of the resulting amines (8 and 14, respectively) using titanium (IV) chloride.

  DOI：

  10.1016/s0040-4020(01)80649-9
• 作为产物：
  描述：

  Methyl 2-((tert-butoxycarbonyl)amino)-3-oxobutanoate 在 盐酸 、 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 生成 α-Benzyloxycarbonylamino-acetessigsaeuremethylester
  参考文献：
  名称：

  Pd-catalyzed enantioselective synthesis of quaternary α-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide

  摘要：

  A Pd-catalyzed enantio selective synthesis of quaternary alpha-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide is described. Asymmetric allylic substitution using acyclic beta-keto esters with a nitrogen functional group at the alpha-carbon as prochiral nucleophiles proceeded in the presence of 5 mol % of Pd catalyst, 10 mol % of chiral diaminophosphine oxide 1j, BSA, and appropriate additives, affording the corresponding quaternary alpha-amino acid derivatives in excellent yield and in up to 92% ee. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.020

文献信息

• COMPOUNDS FOR THE TREATMENT OF BOVINE OR SWINE RESPIRATORY DISEASE
  申请人：Intervet International B.V.

  公开号：EP3558284A2

  公开（公告）日：2019-10-30
• Compounds for the Treatment of Bovine or Swine Respiratory Disease
  申请人：Intervet Inc.

  公开号：US20200085779A1

  公开（公告）日：2020-03-19

  The present invention provides compounds for use in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).
• [EN] COMPOUNDS FOR THE TREATMENT OF BOVINE OR SWINE RESPIRATORY DISEASE<br/>[FR] COMPOSÉS POUR LE TRAITEMENT D'UNE MALADIE RESPIRATOIRE BOVINE OU PORCINE
  申请人：INTERVET INT BV

  公开号：WO2018115432A2

  公开（公告）日：2018-06-28

  The present invention provides compounds for use in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).