(4-amino-3-iodo)-D-Phe-c[Cys-(3-iodo)-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH2 | 846569-60-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4-amino-3-iodo)-D-Phe-c[Cys-(3-iodo)-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH2
• 英文别名: H-(4-Amino-3-iodo)-D-Phe-c(Cys-(3-iodo)-Tyr-D-Trp-Lys-Val-Cys)-Thr-NH2；(4R,7S,10S,13R,16S,19R)-19-[[(2R)-2-amino-3-(4-amino-3-iodophenyl)propanoyl]amino]-10-(4-aminobutyl)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-16-[(4-hydroxy-3-iodophenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
• CAS: 846569-60-6
• 化学式: C₅₀H₆₆I₂N₁₂O₁₀S₂
• 分子量: 1313.09
• InChiKey: ISZMJWBQCGWNNM-DQIXCUPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  76
• 可旋转键数：
  17
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  432
• 氢给体数：
  14
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  (S)-2-(benzylcarbonylamino)-propanol 在 水 、 苯甲醚 、 三氟乙酸 作用下， 反应 1.0h， 生成 (4-amino-3-iodo)-D-Phe-c[Cys-(3-iodo)-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH2
  参考文献：
  名称：

  [EN] SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE
  [FR] ANALOGUES DE SOMATOSTATINE A ACTIVITE INHIBITRICE DE LIBERATION D'HORMONE DE CROISSANCE

  摘要：

  公开号：

  WO2005018682A3

文献信息

• Discovery of Iodinated Somatostatin Analogues Selective for hsst2 and hsst5 with Excellent Inhibition of Growth Hormone and Prolactin Release from Rat Pituitary Cells
  作者：Sandra Blaj Moore、Joost van der Hoek、Antonia de Capua、Peter M. van Koetsveld、Leo J. Hofland、Steven W. J. Lamberts、Murray Goodman

  DOI：10.1021/jm050376t

  日期：2005.10.1

  Inhibition of growth hormone (GH) and prolactin (PRL) release from the anterior pituitary gland is mediated through somatostatin receptor subtypes sst2 and sst5. It has been found that somatostatin (SS) analogues that are selective for both receptor subtypes are more effective at inhibiting GH and PRL release than monospecific analogues alone. We synthesized several disulfide-bridged octapeptide SS analogues. Iodinated compounds 7, (4-amino-3-iodo)-D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH2, and 9,(4-amino-3-iodo)-D-Phe-c[Cys-(3-iodo)-Tyr-D-Trp-Lys-Val-Cys]-Thr-NH2, were as potent as somatostatin in binding at receptors hsst2 and hsst5 and inhibited GH and PRL release from rat pituitary cells as potently as somatostatin.
• [EN] SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE<br/>[FR] ANALOGUES DE SOMATOSTATINE A ACTIVITE INHIBITRICE DE LIBERATION D'HORMONE DE CROISSANCE
  申请人：UNIV CALIFORNIA

  公开号：WO2005018682A3

  公开（公告）日：2005-04-28