1-ethyl-4-isopropylidenehydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid | 37801-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 1-ethyl-4-isopropylidenehydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid
• 英文别名: 1-Ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylic acid
• CAS: 37801-92-6
• 化学式: C₁₂H₁₅N₅O₂
• 分子量: 261.283
• InChiKey: PYMRDGZGXBFUKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  92.4
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Nitric oxide donors in therapy of nitric oxide deficiency-induced disturbances of cerebral microcirculation
  申请人：Universitätsklinikum Münster

  公开号：EP2468269A1

  公开（公告）日：2012-06-27

  The present invention relates to nitric oxide releasing compounds and their use in the prevention, amelioration and/or therapy of nitric oxide (NO) deficiency induced disturbances of the cerebral microcirculation. The NO deficiency induced disturbances of the cerebral microcirculation may be due to an intracranial hemorrhage or stroke and can cause cerebrovascular spasms (or cerebral vasospasms) (CVS) and/or malperfusion of brain parenchyma caused by blood vessel and blood flow dysregulation which, in turn, can cause secondary neurological deficiencies (DIND) and/or brain infarction. Particularly, the present invention relates to the prevention, amelioration and/or therapy of delayed cerebral vasospasm-associated disorders after survived subarachnoidal hemorrhage by applying a NO-donor, most preferably Molsidomine.

  本发明涉及一氧化氮释放化合物及其在预防、改善和/或治疗一氧化氮（NO）缺乏引起的脑微循环障碍中的用途。一氧化氮缺乏引起的脑微循环障碍可能是由颅内出血或中风引起的，可导致脑血管痉挛（或脑血管痉挛）（CVS）和/或由血管和血流失调引起的脑实质灌注不良，进而导致继发性神经功能缺损（DIND）和/或脑梗塞。特别是，本发明涉及通过应用一种 NO 供体，最优选的是莫西多明，来预防、改善和/或治疗存活的蛛网膜下腔出血后迟发性脑血管痉挛相关疾病。
• Methods and compositions for improving sleep
  申请人：——

  公开号：US20020015740A1

  公开（公告）日：2002-02-07

  Methods and compositions for improving sleep in individuals with sleep disorders or other conditions which interfere with normal sleep via administration of a NO-mimetic are provided.

  本研究提供了通过服用 NO 拟态物质改善睡眠障碍患者或其他干扰正常睡眠的患者睡眠的方法和组合物。
• NITRIC OXIDE DONORS IN THERAPY OF NITRIC OXIDE DEFICIENCY-INDUCED DISTURBANCES OF CEREBRAL MICROCIRCULATION
  申请人：Westfälische Wilhelms-Universität Münster

  公开号：EP2642997A1

  公开（公告）日：2013-10-02
• Use of pyrazolopyridines for the treatment of cognitive deficits
  申请人：Schweighoffer Fabien

  公开号：US20060142326A1

  公开（公告）日：2006-06-29

  The invention relates to methods which are used to improve, increase or facilitate the cognition of individuals with neurodegenerative pathologies. More specifically, the invention relates to the use of compounds from the family of pyrazolopyridines in order to improve the cognitive faculties of individuals with neurodegenerative diseases. The invention can be used to improve the condition of individuals with different neurodegenerative diseases and, in particular, Alzheimer's disease and vascular dementia.
• COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY
  申请人：Maibach Todd

  公开号：US20080193385A1

  公开（公告）日：2008-08-14

  The present invention relates to compositions and methods for alleviating the painful symptoms due to neuropathy. Specifically, the method involves administering to a patient a composition comprising a nitric oxide donor that may be applied topically on the legs or arms to alleviate the negative effects due to neuropathy.