(3R,3aS,6S,6aS)-6-((bis(diethylamino)phosphaneyl)oxy)hexahydrofuro[3,2-b]furan-3-yl ((3S,3aS,6R,6aS)-6-((bis(diethylamino)phosphaneyl)oxy)hexahydrofuro[3,2-b]furan-3-yl) diethylphosphoramidite | 848773-08-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (3R,3aS,6S,6aS)-6-((bis(diethylamino)phosphaneyl)oxy)hexahydrofuro[3,2-b]furan-3-yl ((3S,3aS,6R,6aS)-6-((bis(diethylamino)phosphaneyl)oxy)hexahydrofuro[3,2-b]furan-3-yl) diethylphosphoramidite
• CAS: 848773-08-0
• 化学式: C₃₂H₆₆N₅O₈P₃
• 分子量: 741.826
• InChiKey: QVJBQMLFYFYWCI-IFAUNLHASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.51
• 重原子数：
  48.0
• 可旋转键数：
  23.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.04
• 氢给体数：
  0.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  (3R,3aS,6S,6aS)-6-((bis(diethylamino)phosphaneyl)oxy)hexahydrofuro[3,2-b]furan-3-yl ((3S,3aS,6R,6aS)-6-((bis(diethylamino)phosphaneyl)oxy)hexahydrofuro[3,2-b]furan-3-yl) diethylphosphoramidite 在 sulfur 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 以0.89 g的产率得到bis-[5-O-[bis(diethylamino)thiophosphoryl]-1,4:3,6-dianhydro-D-sorbitol-2-O-yl]-(diethylamino)thionophosphate
  参考文献：
  名称：

  Features of Phosphorylation of 1,4:3,6-Dianhydro-D-sorbitol with Phenylphosphonamidous and Phosphoramidous Chlorides: An Approach to the Directed Synthesis of Oligophosphites and Oligophosphonites

  摘要：

  DOI：

  10.1023/b:doch.0000035396.16769.a3
• 作为产物：
  描述：

  双(二乙基氨基)氯膦 、 异山梨醇 在 三乙胺 作用下， 以 苯 为溶剂， 生成 (3R,3aS,6S,6aS)-6-((bis(diethylamino)phosphaneyl)oxy)hexahydrofuro[3,2-b]furan-3-yl ((3S,3aS,6R,6aS)-6-((bis(diethylamino)phosphaneyl)oxy)hexahydrofuro[3,2-b]furan-3-yl) diethylphosphoramidite
  参考文献：
  名称：

  Hydroxyoligophosphites and -Phosphonites on the Basis of 1,4:3,6-Dianhydro-D-sorbitol

  摘要：

  The interaction of 1,4:3,6-dianhydro-D-sorbitol with phosphorous and phenylphosphonous acid amidochlorides leads to oligophosphites and -phosphonites with free hydroxyl groups on the periphery of their molecules. The obtained compounds were introduced into reactions via the transformation of trivalent phosphorus and hydroxyl groups.

  DOI：

  10.1080/104265090930335