isobutyl 4-(4-ethoxyphenyl)-3-iodo-7-trifluoromethyl-2-(cyclohex-1-enyl)-9H-pyrido[2,3-b]indole-9-carboxylate | 1262587-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: isobutyl 4-(4-ethoxyphenyl)-3-iodo-7-trifluoromethyl-2-(cyclohex-1-enyl)-9H-pyrido[2,3-b]indole-9-carboxylate
• CAS: 1262587-64-3
• 化学式: C₃₁H₃₀F₃IN₂O₃
• 分子量: 662.491
• InChiKey: HFASZCOBRUURJQ-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 一氯化碘 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 1.0h， 以0.274 g的产率得到isobutyl 4-(4-ethoxyphenyl)-3-iodo-7-trifluoromethyl-2-(cyclohex-1-enyl)-9H-pyrido[2,3-b]indole-9-carboxylate
  参考文献：
  名称：

  Three component tandem reactions involving protected 2-amino indoles, disubstituted propargyl alcohols, and I2/ICl: iodo-reactant controlled synthesis of dihydro-α-carbolines and α-carbolines via iodo-cyclization/iodo-cycloelimination

  摘要：

  Two simple, highly efficient three component tandem reactions for the synthesis of diversified N-a N-b dicarbamate-4,9-dihydro-3-iodo-alpha-carbolines and N-a-carbamate-3-iodo-alpha-carbolines have been described. The strategy involves one-pot condensation of bis-carbamate protected 2-amino indoles with disubstituted propargyl alcohols and I-2/ICl. The salient feature of the reaction involves iodocyclo-elimination of N-b-linked carbamate under mild condition in the final step. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.147