8-Chlor-11-(p-nitro-benzylmercapto)-5H-dibenzo-1,4-diazepin | 15980-85-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 8-Chlor-11-(p-nitro-benzylmercapto)-5H-dibenzo-1,4-diazepin
• 英文别名: 8-chloro-11-(4-nitro-benzylsulfanyl)-5H-dibenzo[b,e][1,4]diazepine；3-chloro-6-[(4-nitrophenyl)methylsulfanyl]-11H-benzo[b][1,4]benzodiazepine
• CAS: 15980-85-5
• 化学式: C₂₀H₁₄ClN₃O₂S
• 分子量: 395.869
• InChiKey: BXKLQDVUEDNLEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  95.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Methods for Treating Diseases of the Retina
  申请人：Kusari Jyotirmoy

  公开号：US20120142675A1

  公开（公告）日：2012-06-07

  Disclosed herein is a method of treating disorders of the retina comprising administering to a patient in need of such treatment a compound selected from the group consisting of olanzapine, certain of its metabolites, clozapine, and n-desmethyl clozapine.
• METHODS FOR TREATING DISEASES OF THE RETINA
  申请人：Allergan, Inc.

  公开号：US20150290215A1

  公开（公告）日：2015-10-15

  Disclosed herein is a method of treating disorders of the retina comprising administering to a patient in need of such treatment a compound selected from the group consisting of olanzapine, certain of its metabolites, clozapine, and n-desmethyl clozapine.
• US9018202B2
  申请人：——

  公开号：US9018202B2

  公开（公告）日：2015-04-28
• US9561234B2
  申请人：——

  公开号：US9561234B2

  公开（公告）日：2017-02-07
• [EN] METHODS FOR TREATING DISEASES OF THE RETINA<br/>[FR] PROCÉDÉS DE TRAITEMENT DE MALADIES DE LA RÉTINE
  申请人：ALLERGAN INC

  公开号：WO2012074788A1

  公开（公告）日：2012-06-07

  Disclosed herein is a method of treating disorders of the retina comprising administering to a patient in need of such treatment a compound selected from the group consisting of olanzapine, certain of its metabolites, clozapine, and n-desmethyl clozapine.