yttrium(III) 1,4,7-tris[4'-(ethoxycarbonyl)-1'-carboxybutyl]-1,4,7,10-tetraazacyclododecane | 1186243-17-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: yttrium(III) 1,4,7-tris[4'-(ethoxycarbonyl)-1'-carboxybutyl]-1,4,7,10-tetraazacyclododecane
• CAS: 1186243-17-3
• 化学式: C₃₂H₅₃N₄O₁₂Y
• 分子量: 774.698
• InChiKey: QIXZTXAKULFTFP-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1,4,7-tris[4'-(ethoxycarbonyl)-1'-carboxybutyl]-1,4,7,10-tetraazacyclododecane 、 yttrium(III) chloride hexahydrate 在 sodium hydroxide 作用下， 以 水 为溶剂， 以93%的产率得到yttrium(III) 1,4,7-tris[4'-(ethoxycarbonyl)-1'-carboxybutyl]-1,4,7,10-tetraazacyclododecane
  参考文献：
  名称：

  Luminescence Study of Eu(III) Analogues of Esterase-Activated Magnetic Resonance Contrast Agents

  摘要：

  A model for an accumulation and enzyme-activation strategy of a magnetic resonance contrast agent was investigated via the luminescence of Eu(III) analogues. Neutral q = 2 Eu(III) ethyl and acetoxymethyl ester LnaDO3A-based complexes showed increased emission intensity in the presence of serum concentrations of carbonate because of inner-sphere water molecule displacement by the anion. The affinity for carbonate is suppressed by the introduction of negative charge to the complex following enzymatic hydrolysis of the ester groups, resulting in quenching of Eu(Ill) luminescence and changes in spectral form. The conversion of neutral, catoxylic ester-containing complexes into free acid forms by enzymatic hydrolysis using pig liver esterase was demonstrated by luminescence (Eu) and H-1 NMR spectroscopic investigations (Y). These studies demonstrated that the concept of inhibition of anion binding as a result of enzyme activation is feasible.

  DOI：

  10.1021/ic901284t