N^α-Benzyloxycarbonyl-N^δ-phthalyl-ornithin | 100301-69-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N^α-Benzyloxycarbonyl-N^δ-phthalyl-ornithin
• 英文别名: N-Cbz-5-phthalimido-L-norvaline；5-(1,3-dioxoisoindol-2-yl)-2-(phenylmethoxycarbonylamino)pentanoic acid
• CAS: 100301-69-7
• 化学式: C₂₁H₂₀N₂O₆
• 分子量: 396.4
• InChiKey: QCLYZAIZBKHBFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Melanocortin receptor-specific compounds
  申请人：Palatin Technologies, Inc.

  公开号：US20040224957A1

  公开（公告）日：2004-11-11

  A melanocortin receptor-specific compound of the general formula of structure I: 1 where X, R 1 , R 2a , R 2b , R 3 , R 4a , R 4b , R 5a and R 5b are as defined in the specification, which compound binds with high affinity to one or more melanocortin receptors and is optionally an agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist, and may be employed for treatment of one or melanocortin receptor-associated conditions or disorders, and methods for the use of the compounds of the invention.

  一种具有结构I：1的一般式的黑素皮质素受体特异性化合物，其中X、R1、R2a、R2b、R3、R4a、R4b、R5a和R5b如说明书中所定义，该化合物与一个或多个黑素皮质素受体高亲和结合，并可选择性地为激动剂、拮抗剂、逆拮抗剂或逆拮抗剂的拮抗剂，并可用于治疗一个或多个黑素皮质素受体相关疾病或疾病，并且使用该发明化合物的方法。
• Substituted melanocortin receptor-specific piperazine compounds
  申请人：Sharma D. Shubh

  公开号：US20050176728A1

  公开（公告）日：2005-08-11

  Melanocortin receptor-specific compounds of the general formulas and pharmaceutically acceptable salts thereof, where J is a substituted or unsubstituted monocyclic or bicyclic ring structure, L is a linker, W is a heteroatom unit with at least one cationic center, hydrogen bond donor or hydrogen bond acceptor, Q includes a substituted or unsubstituted aromatic carbocyclic ring, R 6 , R 7 , y and z are as defined in the specification, and the carbon atom marked with an asterisk can have any stereochemical configuration, and optionally with one or two additional ring substituents as defined, which compounds bind to one or more melanocortin receptors and are optionally an agonist, a partial agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist, and may be employed for treatment of one or more melanocortin receptor-associated conditions or disorders, and methods for the use of the compounds of the invention.

  具有以下一般式及其药学上可接受的盐的黑色素皮质素受体特异性化合物，其中J是取代或未取代的单环或双环环结构，L是连接子，W是具有至少一个阳离子中心、氢键供体或氢键受体的杂原子单元，Q包括取代或未取代的芳香环烷基环，R6、R7、y和z如规范中所定义，标有星号的碳原子可以具有任何立体化学构型，并且可选择具有一个或两个附加环取代基，所述化合物结合一个或多个黑色素皮质素受体，可选择是激动剂、部分激动剂、拮抗剂、反向激动剂或反向激动剂的拮抗剂，并可用于治疗一个或多个黑色素皮质素受体相关的疾病或症状，并提供了使用该发明化合物的方法。
• Piperazine melanocortin-specific compounds
  申请人：Palatin Technologies, Inc.

  公开号：US20040157264A1

  公开（公告）日：2004-08-12

  Melanocortin receptor-specific piperazine or ketopiperazine compounds having the structure: 1 and stereoisomer and pharmaceutically acceptable salts thereof, where X is CH 2 or C═O, R 1 , R 2 , and R 3 are as described in the specification, preferably where R 3 is a D-amino acid with at least one substituted or unsubstituted phenyl or naphthyl aromatic ring, and where R 3 optionally further includes an amine capping group, a second amino acid residue or a second amino acid residue with an amine capping group, which compounds are agonists, antagonists or mixed agonists and antagonists at one or more melanocortin receptors, and having utility in the treatment of melanocortin receptor-related disorders and conditions. Methods of synthesis of compounds of structure (I), pharmaceutical compositions containing a compound of structure (I) and methods relating to the use thereof are also disclosed.

  具有以下结构的黑素皮质素受体特异性哌嗪或酮哌嗪化合物：1和立体异构体及其药学上可接受的盐，其中X为CH2或C═O，R1、R2和R3如规范所述，优选R3为至少具有一个取代或未取代的苯基或萘基芳香环的D-氨基酸，其中R3还可以包括胺基端盖基团、第二个氨基酸残基或带有胺基端盖基团的第二个氨基酸残基，这些化合物是黑素皮质素受体的激动剂、拮抗剂或混合激动剂和拮抗剂，在治疗黑素皮质素受体相关的疾病和病况方面具有用途。还公开了化合物(I)的合成方法、含有化合物(I)的制药组合物以及与其使用相关的方法。
• Peptidomimetics of biologically active metallopeptides
  申请人：Palatin Technologies, Inc.

  公开号：US20040171520A1

  公开（公告）日：2004-09-02

  The invention relates to a method of deriving a peptidomimetic of a biologically active metallopeptide, wherein the peptidomimetic includes at least one non-peptide ring structure defining a template space superimposable on a corresponding defined template space of the metallopeptide, and where the peptidomimetic further includes at least two elements independently including an amino acid residue, amino acid side chain moiety or derivative thereof, the elements defining and occupying a similar descriptor space as corresponding elements of the metallopeptide. The invention further relates to peptidomimetics with a template space heterocyclic ring structure, including 5-, 6- and 8-membered and 5-5- and 6-5-bicyclic fused ring structure melanocortin receptor-specific peptidomimetics.

  本发明涉及一种导出生物活性金属肽的肽类类似物的方法，其中该肽类类似物包括至少一个非肽环结构，该非肽环结构定义了一个模板空间，可以与金属肽的相应定义模板空间相重叠。肽类类似物还包括至少两个元素，这些元素独立地包括氨基酸残基、氨基酸侧链基团或其衍生物，这些元素定义并占据与金属肽的相应元素类似的描述符空间。本发明还涉及带有模板空间杂环环结构的肽类类似物，包括5、6和8个成员以及5-5-和6-5-融合环结构的黑素皮质素受体特异性肽类类似物。
• Melanocortin Receptor-Specific Compounds
  申请人：Sharma Shubh D.

  公开号：US20080234289A1

  公开（公告）日：2008-09-25

  A melanocortin receptor-specific compound of the general formula of structure I: where X, R 1 , R 2a , R 2b , R 3 , R 4a , R 4b , R 5a and R 5b are as defined in the specification, which compound binds with high affinity to one or more melanocortin receptors and is optionally an agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist, and may be employed for treatment of one or melanocortin receptor-associated conditions or disorders, and methods for the use of the compounds of the invention.

  一种具有结构I的通式的黑素细胞激素受体特异性化合物，其中X、R1、R2a、R2b、R3、R4a、R4b、R5a和R5b如规范中所定义，该化合物与一个或多个黑素细胞激素受体具有高亲和力，并且可以是激动剂、拮抗剂、反向激动剂或反向激动剂的拮抗剂，可用于治疗一个或多个黑素细胞激素受体相关的疾病或症状，并提供了使用该发明化合物的方法。