(2S)-5-[5-(3-benzyloxy-2-tert-butoxycarbonylamino-propoxy)-pyridin-3-yl]-3-methyl-indazole-1-carboxylic acid tert-butyl ester | 552331-51-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: (2S)-5-[5-(3-benzyloxy-2-tert-butoxycarbonylamino-propoxy)-pyridin-3-yl]-3-methyl-indazole-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl 3-methyl-5-[5-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylmethoxypropoxy]pyridin-3-yl]indazole-1-carboxylate
• CAS: 552331-51-8
• 化学式: C₃₃H₄₀N₄O₆
• 分子量: 588.704
• InChiKey: FKFIKHKTIKWGRC-SANMLTNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  43
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Kinase inhibitors
  申请人：——

  公开号：US20030187026A1

  公开（公告）日：2003-10-02

  Compounds having the formula 1 are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

  具有以下化学式的化合物对抑制蛋白激酶很有用。还公开了抑制蛋白激酶的组合物以及在患者中抑制蛋白激酶的方法。
• 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Abbott Laboratories

  公开号：EP1463505A2

  公开（公告）日：2004-10-06
• US6831175B2
  申请人：——

  公开号：US6831175B2

  公开（公告）日：2004-12-14
• [EN] KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASE
  申请人：ABBOTT LAB

  公开号：WO2003051366A2

  公开（公告）日：2003-06-26

  Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.