| 1429615-69-9

• 分子结构分类: 有机化合物
• CAS: 1429615-69-9
• 化学式: C₈₆H₁₂₉N₇O₁₄S
• 分子量: 1517.07
• InChiKey: JNMLRXOTCBSHQZ-WSFJHVQVSA-N

反应信息

• 作为产物：
  描述：

  (1S,3R,4R,5S,7S,8R,9S,12R,13R,18R,21S,22S,24R,25R,26S,28S,29R,30S,33R,34R,39R,42S,43S,45R,46R,47S,49S,50R,51S,54R,55R,60R,63R,66S)-3,7,24,28,45,49-hexahydroxy-8,13,21,29,34,42,50,55,66-nonamethyl-60-(prop-2-ynylsulfanylmethyl)-17,38,59,62-tetrazatridecacyclo[61.3.1.118,22.139,43.04,9.05,66.08,12.021,26.025,30.029,33.042,47.046,51.050,54]nonahexacontane-16,37,58,61-tetrone 、 3,5-dicarboxyphenyl azide 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 以66%的产率得到
  参考文献：
  名称：

  Tuning Nanopore Formation of Oligocholate Macrocycles by Carboxylic Acid Dimerization in Lipid Membranes

  摘要：

  Oligocholate macrocycles self-assemble into transmembrane nanopores by the associative interactions of water molecules inside the amphiphilic macrocycles. Macrocycles functionalized with a terephthalic a acid "side chain" displayed significantly higher transport activity for glucose across lipid bilayers than the corresponding methyl ester derivative. Changing the 1,4-substitution of the carboxylic acid to 1,3-substitution lowered the activity. Combining the hydrophobic interactions and the hydrogen-bond-based carboxylic acid dimerization was an effective strategy to tune the structure and activity of self-assembled nanopores in lipid membranes.

  DOI：

  10.1021/jo400455x