(E)-3-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acrylamido)azetidine-1-carboxamide | 1259013-78-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (E)-3-(3-(2,6,6-trimethylcyclohex-1-en-1-yl)acrylamido)azetidine-1-carboxamide
• 英文别名: 3-[[(E)-3-(2,6,6-trimethylcyclohexen-1-yl)prop-2-enoyl]amino]azetidine-1-carboxamide
• CAS: 1259013-78-9
• 化学式: C₁₆H₂₅N₃O₂
• 分子量: 291.393
• InChiKey: GUERZJJETJDRQR-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE<br/>[FR] LIGANDS DE LIAISON À L'OPSINE, COMPOSITIONS ET PROCÉDÉS D'UTILISATION
  申请人：BIKAM PHARMACEUTICALS INC

  公开号：WO2010147653A1

  公开（公告）日：2010-12-23

  Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.

  本文披露了用于治疗与视蛋白蛋白质错位、突变视蛋白蛋白质的错误折叠以及在眼睛中积累的有毒视觉循环产物有关的眼科疾病的化合物及该化合物的组合物，以及使用该化合物的方法。还描述了在这些方法中有用的化合物和组合物，无论是单独使用还是与其他治疗剂联合使用。
• Opsin-binding ligands, compositions and methods of use
  申请人：Garvey David S.

  公开号：US20110003784A1

  公开（公告）日：2011-01-06

  Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.

  本文披露了用于治疗与视蛋白蛋白质错位、突变视蛋白蛋白质的错折和在眼中积累有毒视觉循环产物相关的眼科疾病的化合物和该化合物的组合物以及使用该化合物的方法。本文还描述了用于这些方法的化合物和组合物，可以单独使用或与其他治疗药物联合使用。
• OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE
  申请人：Bikam Pharmaceuticals, Inc.

  公开号：EP2442644A1

  公开（公告）日：2012-04-25
• Opsin-Binding Ligands, Compositions and Methods of Use
  申请人：BIKAM PHARMACEUTICALS INC.

  公开号：US20170037018A1

  公开（公告）日：2017-02-09

  Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.
• US9562022B2
  申请人：——

  公开号：US9562022B2

  公开（公告）日：2017-02-07