2-fluoro-3-methoxy-1-N-[2-(7-methoxy-1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine | 1132682-24-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-fluoro-3-methoxy-1-N-[2-(7-methoxy-1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine
• CAS: 1132682-24-6
• 化学式: C₂₃H₂₃FN₄O₂
• 分子量: 406.46
• InChiKey: LZKMJUIKACMQPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  71.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53<br/>[FR] INHIBITEURS DE L'INTERACTION ENTRE MDM2 ET P53
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009037308A1

  公开（公告）日：2009-03-26

  The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds; wherein n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, R20, X, Y, Q and Z have defined meanings.

  本发明提供了式（I）的化合物，其作为p53-MDM2相互作用抑制剂的用途，以及包含所述化合物的药物组合物；其中n、m、p、s、t、R1、R2、R3、R4、R5、R6、R7、R20、X、Y、Q和Z具有定义的含义。
• Inhibitors of the Interaction Between MDM2 and P53
  申请人：Poncelet Virginie Sophie

  公开号：US20100240637A1

  公开（公告）日：2010-09-23

  The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds: wherein n, m, p, s, t, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 20 , X, Y, Q and Z have defined meanings.
• INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53
  申请人：Janssen Pharmaceutica NV

  公开号：US20170112818A1

  公开（公告）日：2017-04-27

  The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds: wherein n, m, p, s, t, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 20 , X, Y, Q and Z have defined meanings.
• Inhibitors Of The Interaction Between MDM2 And P53
  申请人：Janssen Pharmaceutica NV

  公开号：US20200121667A1

  公开（公告）日：2020-04-23

  The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds: wherein n, m, p, s, t, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 20 , X, Q and Z have defined meanings.
• US9573933B2
  申请人：——

  公开号：US9573933B2

  公开（公告）日：2017-02-21