5-methyl-4-chloro-1-hydroxy-1,2-dihydrophosphorin 1-oxide | 115141-76-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: 5-methyl-4-chloro-1-hydroxy-1,2-dihydrophosphorin 1-oxide
• 英文别名: 4-chloro-1-hydroxy-5-methyl-2H-1lambda5-phosphinine 1-oxide；4-chloro-1-hydroxy-5-methyl-2H-1λ5-phosphinine 1-oxide
• CAS: 115141-76-9
• 化学式: C₆H₈ClO₂P
• 分子量: 178.555
• InChiKey: HVQJCJMIWKUQEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6,6-dichloro-3-methoxy-1-methyl-3-phosphabicyclo<3.1.0>hexane 3-oxide 以44%的产率得到
  参考文献：
  名称：

  KEGLEVICH, GYORGY;TOKE, LASZLO;ANDROSITS, BEATA, MAGY KEM. FOLYOIRAT., 95,(1989) N, C. 84-86

  摘要：

  DOI：

文献信息

• Synthesis of Functionalized P-Heterocycles Including Phosphine-Borane Complexes
  作者：György Keglevich、László Tõke、Kálmán Újszászy、ÁRon SzÕllõsy

  DOI：10.1080/10426509608545189

  日期：1996.1

  Abstract Preparation of phosphinic chlorides, amides, and sulfide derivatives, as well as phosphine-borane complexes of P-heterocycles is described.

  摘要 描述了次膦酰氯化物、酰胺和硫化物衍生物以及 P-杂环的膦-硼烷配合物的制备。
• Synthesis of dihydrophosphorins by the thermal transformation of phosphole-dichlorocarbene adducts
  作者：Gyorgy Keglevich、Beata Androsits、Laszlo Toke

  DOI：10.1021/jo00252a043

  日期：1988.8
• KEGLEVICH, GYORGY;TOKE, LASZLO;ANDROSITS, BEATA, MAGY KEM. FOLYOIRAT., 95,(1989) N, C. 84-86
  作者：KEGLEVICH, GYORGY、TOKE, LASZLO、ANDROSITS, BEATA

  DOI：——

  日期：——
• KEGLEVICH, GYORGY;ANDROSITS, BEATA;TOKE, LASZLO, J. ORG. CHEM., 53,(1988) N 17, 4106-4108
  作者：KEGLEVICH, GYORGY、ANDROSITS, BEATA、TOKE, LASZLO

  DOI：——

  日期：——
• Cyclic Phosphinates by the Alkylation of a Thermally Unstable 1-Hydroxy-1,2- Dihydrophosphinine 1-Oxide and A 3-Hydroxy-3-Phosphabicyclo[3.1.0]Hexane 3-Oxide
  作者：Erzsébet Jablonkai、Erika Bálint、György T. Balogh、László Drahos、György Keglevich

  DOI：10.1080/10426507.2011.613876

  日期：2012.3.1

  1-alkoxy-1,2-dihydrophosphinine oxides 4 may be prepared by the reaction of 1-hydroxy-1,2-dihydrophosphinine 1-oxide 3 with alkyl halides. The best results were obtained in boiling acetone in the presence of K2CO3. The outcome of the alkylation of 3-hydroxy-6,6-dichloro-3-phosphabicyclo[3.1.0]hexane 3-oxide 5 was dependent on temperature. Butylation at 56 degrees C in acetone using K2CO3 afforded mainly the expected phosphinate 6, but an increase in the temperature led to opening of the cyclopropane ring, resulting in the formation of 1-butoxy-1,2-dihydrophosphinine oxide 4a as the major product.