uracil-EDOT | 1174522-42-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: uracil-EDOT
• 英文别名: EDOT-uracil；1-(2,3-Dihydrothieno[3,4-b][1,4]dioxin-3-ylmethyl)pyrimidine-2,4-dione；1-(2,3-dihydrothieno[3,4-b][1,4]dioxin-3-ylmethyl)pyrimidine-2,4-dione
• CAS: 1174522-42-9
• 化学式: C₁₁H₁₀N₂O₄S
• 分子量: 266.277
• InChiKey: QLIPRRUDXMAZOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  96.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(氯甲基)-2,3-二氢-噻吩并[3,4-b]-1,4-二噁英 、 尿嘧啶 在 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 以31%的产率得到uracil-EDOT
  参考文献：
  名称：

  Specific recognition of a nucleobase-functionalized poly(3,4-ethylenedioxithiophene) (PEDOT) in aqueous media

  摘要：

  In this Letter we report the synthesis, characterization, and electrochemical investigation of a 3,4-ethylenedioxythiophene (EDOT) derivative covalently linked to the nucleobase uracil. The successful electrochemical polymerization of this derivative has provided modified electrodes with a novel functional poly(3,4-ethylenedioxythiophene) derivative. Recognition experiments in aqueous media have shown the specific recognition of the complementary base adenine. The electrochemical detection of the selective binding of nucleobases to this PEDOT derivative in aqueous media can be of particular interest for electrochemical sensor applications in physiological media. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.119

文献信息

• Specific recognition of a nucleobase-functionalized poly(3,4-ethylenedioxithiophene) (PEDOT) in aqueous media
  作者：Raúl Blanco Bazaco、Rafael Gómez、Carlos Seoane、Peter Bäuerle、José L. Segura

  DOI：10.1016/j.tetlet.2009.04.119

  日期：2009.7

  In this Letter we report the synthesis, characterization, and electrochemical investigation of a 3,4-ethylenedioxythiophene (EDOT) derivative covalently linked to the nucleobase uracil. The successful electrochemical polymerization of this derivative has provided modified electrodes with a novel functional poly(3,4-ethylenedioxythiophene) derivative. Recognition experiments in aqueous media have shown the specific recognition of the complementary base adenine. The electrochemical detection of the selective binding of nucleobases to this PEDOT derivative in aqueous media can be of particular interest for electrochemical sensor applications in physiological media. (C) 2009 Elsevier Ltd. All rights reserved.