2-(N-methylbenzamido)-5-(2-O,4-C-methylene-D-ribofuranosyl)thiazole | 1029931-26-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(N-methylbenzamido)-5-(2-O,4-C-methylene-D-ribofuranosyl)thiazole
• CAS: 1029931-26-7
• 化学式: C₁₇H₁₈N₂O₅S
• 分子量: 362.406
• InChiKey: VWIAKAFBOKJCTF-WSMBLCCSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.98
• 重原子数：
  25.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  92.12
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2-(N-methylbenzamido)-5-(2-O,4-C-methylene-D-ribofuranosyl)thiazole 、 4,4'-双甲氧基三苯甲基氯 以 吡啶 为溶剂， 反应 12.0h， 以96%的产率得到2-(N-methylbenzamido)-5-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-D-ribofuranosyl]thiazole
  参考文献：
  名称：

  Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation

  摘要：

  2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) monomers bearing novel unnatural nucleobases, 4-(3-benzamidophenyl)-2-pyridone and 2-(N-methylbenzamido)thiazole, were synthesized and successfully incorporated into oligonucleotides. UV melting experiments showed that the corresponding oligonucleotide derivatives formed stable triplexes with dsDNA targets even in the presence of a T center dot A interruption. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.12.043
• 作为产物：
  描述：

  2-(N-methylbenzamido)-5-(3,5-di-O-tert-butyldiphenylsilyl-2-O,4-C-methylene-D-ribofuranosyl)thiazole 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以72%的产率得到2-(N-methylbenzamido)-5-(2-O,4-C-methylene-D-ribofuranosyl)thiazole
  参考文献：
  名称：

  Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation

  摘要：

  2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) monomers bearing novel unnatural nucleobases, 4-(3-benzamidophenyl)-2-pyridone and 2-(N-methylbenzamido)thiazole, were synthesized and successfully incorporated into oligonucleotides. UV melting experiments showed that the corresponding oligonucleotide derivatives formed stable triplexes with dsDNA targets even in the presence of a T center dot A interruption. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.12.043