Eu(N,N''-bis(2-methoxyethylamide-carbamoylmethyl)diethylenetriamine-N,N',N''-triacetate) | 186596-82-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Eu(N,N''-bis(2-methoxyethylamide-carbamoylmethyl)diethylenetriamine-N,N',N''-triacetate)
• CAS: 186596-82-7
• 化学式: C₂₀H₃₄N₅O₁₀*Eu
• 分子量: 656.477
• InChiKey: DUPGFOYGZUBQJU-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -7.33
• 重原子数：
  36.0
• 可旋转键数：
  22.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  206.77
• 氢给体数：
  2.0
• 氢受体数：
  13.0

反应信息

• 作为产物：
  描述：

  氢化铕 、 钆8,11-二(羧酸甲基)-14-{2-[(2-甲氧基乙基)氨基]-2-氧代乙基}-6-氧代-2-氧杂-5,8,11,14-四氮杂十六烷-16-酸酯 以 水 为溶剂， 生成 Eu(N,N''-bis(2-methoxyethylamide-carbamoylmethyl)diethylenetriamine-N,N',N''-triacetate)
  参考文献：
  名称：

  The kinetics of exchange between a lanthanide ion and the gadolinium complex of N,N″-bis(2-methoxyethylamide-carbamoylmethyl)-diethylenetriamine-N,N′,N″-triacetate

  摘要：

  The exchange kinetics of Gd(DTPA-BMEA) with the radioactive tracer Eu(III) have been studied in aqueous solution of 0.15 M ionic strength and 25 degrees C. The exchange is a first-order reaction with the rate expression containing both acid-dependent and acid-independent terms. At pH > 6, the exchange is governed by direct reaction of Eu(III) ions with Gd(DTPA-BMEA), while below pH 6, the rate determining step is proton-catalyzed dissociation of the complex with a first-order dependence on [H+]. The relatively slow association and dissociation of the Ln(DTPA-BMEA) complexes can be attributed to steric effects related to the binding of the two methoxyethylamide groups.

  DOI：

  10.1016/s0020-1693(97)05513-8