2,8-dichloro azelaoic acid | 45158-93-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,8-dichloro azelaoic acid
• 英文别名: 2,8-Dichlorononanedioic acid
• CAS: 45158-93-8
• 化学式: C₉H₁₄Cl₂O₄
• 分子量: 257.114
• InChiKey: QMSODKZUDSKGNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  壬二酰氯 在 磺酰氯 、 双氧水 、 碳酸氢钠 作用下， 以 乙醚 为溶剂， 反应 34.0h， 生成 2,8-dichloro azelaoic acid
  参考文献：
  名称：

  Use of acylphosphonates for the synthesis of α-chlorinated carboxylic and α,α′-dichloro dicarboxylic acids and their derivatives

  摘要：

  alpha -Chloro acylphosphonates and alpha,alpha'-dichloro bisacylphosphonates were prepared in situ by chlorination of acylphosphonates and bisacylphosphonates, respectively, using sulfuryl chloride. Subsequently, they were cleaved to the corresponding alpha -chlorinated or alpha,alpha'-dichlorinated (di)carboxylic acids with a hydrogen peroxide-sodium bicarbonate system. Performing the cleavage with an alcohol or an amine yielded the corresponding alpha -chlorinated esters and alpha -chlorinated amides, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00407-0

文献信息

• Pharmaceutical compositions containing alpha-halogenated dicarboxylic acids
  申请人：Epis S.A.

  公开号：EP0279978B1

  公开（公告）日：1992-01-02
• US4214071A
  申请人：——

  公开号：US4214071A

  公开（公告）日：1980-07-22
• US4908385A
  申请人：——

  公开号：US4908385A

  公开（公告）日：1990-03-13
• [EN] MEDICAMENTS CONTAINING ALPHA-HALOGENATED DICARBOXYLIC ACIDS
  申请人：EPIS S.A.

  公开号：WO1988002746A1

  公开（公告）日：1988-04-21

  (EN) Medicaments containing known alpha-halogenated dicarboxylic acids of formula (I), whereby in general formula (I), Hal is fluorine, chlorine and bromine; R is hydrogen and Hal, and m is a number between 4 and 16; or new compounds of general formula (I) in which m is a number between 9 and 16. The invention also includes their pharmacologically compatible salts, esters and amides, processes for the production of such compounds, as well as the use of these compounds for producing medicaments for the treatment of adiposity, hyperlipidemias and diabetes.(FR) Médicaments contenant des acides dicarboxyliques alpha-halogénés connus de formule (I) dans laquelle Hal est fluor, chlore et brome; R est hydrogène et Hal, et m est un nombre entre 4 et 16; ou bien de nouveaux composés de formule générale (I) dans laquelle m est un nombre entre 8 et 16. L'invention concerne également leurs sels, esters et amides pharmacologiquement compatibles, des procédés pour la fabrication desdits composés, ainsi que leur emploi pour fabriquer des médicaments permettant de traiter l'adiposité, l'hyperlipidémie et le diabète.
• [EN] USE OF DICARBOXYLIC ACID COMPOUNDS FOR CONTROLLING PLANT DISEASES<br/>[FR] UTILISATION DE COMPOSÉS D'ACIDE DICARBOXYLIQUE POUR LUTTER CONTRE LES MALADIES DES PLANTES
  申请人：UNIV CHINA AGRICULTURAL

  公开号：WO2020253077A1

  公开（公告）日：2020-12-24

  Disclosed is the use of a dicarboxylic acid compound for controlling plant diseases by fungi and oomycetes, wherein a dicarboxylic acid compound is selected from compounds of formulas (I), (II), (III) and (IV), as well as isomers, hydrates or salts thereof. The dicarboxylic acid compounds have remarkably inhibitory activity against appressorium formation by fungi or oomycetes, and therefore, can be used for controlling diseases, such as rice blast, anthracnose, downy mildew, phytophthora blight, gray mold, etc., with no obvious phytotoxicity and good safety. Compared with fungicides currently used for controlling plant diseases such as rice blast, anthracnose, downy mildew, phytophthora blight, gray mold, etc., the dicarboxylic acid compounds have characteristics such as good preventive effect, environmental friendliness, non-toxicity, low residue, and safety.