4-羟基十二烷-2-酮 | 105230-31-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 4-羟基十二烷-2-酮
• 英文名称: 4-hydroxy-dodecan-2-one
• 英文别名: 4-Hydroxy-dodecan-2-on；4-Hydroxy-2-dodecanal；4-hydroxydodecan-2-one
• CAS: 105230-31-7
• 化学式: C₁₂H₂₄O₂
• 分子量: 200.321
• InChiKey: JZEADDVUBQQNNF-UHFFFAOYSA-N

物化性质

• 熔点：
  34-35 °C
• 沸点：
  298.5±13.0 °C(Predicted)
• 密度：
  0.903±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-羟基十二烷-2-酮 生成 十二碳-3-烯-2-酮
  参考文献：
  名称：

  BURGER, B. V.;PRETORIUS, P. J.;SPIES, H. S. C.;BIGALKE, R. C.;GRIERSON, G+, J. CHEM. ECOL., 16,(1990) N, C. 397-416

  摘要：

  DOI：
• 作为产物：
  描述：

  壬醛 、 propan-2-one O-acetyl oxime 在 nickel dichloride chromium dichloride 、 sodium fluoride 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以67%的产率得到4-羟基十二烷-2-酮
  参考文献：
  名称：

  通过用铬（II）还原O-乙酰肟生成铬烯胺及其应用。

  摘要：

  铬烯胺可以通过一电子还原和连续异构化两个步骤，用铬（II）处理O-乙酰肟而生成，并且该物质与醛反应生成LiAlH4还原后生成γ-氨基醇。

  DOI：

  10.1039/b105357b

文献信息

• Most Infectious Complications in Parenterally Fed Trauma Patients Are Not Due to Elevated Blood Glucose Levels
  作者：Kenneth A. Kudsk、Anne Laulederkind、M. Keith Hanna

  DOI：10.1177/0148607101025004174

  日期：2001.7

  Objective: To determine the relationship between hyperglycemia and infectious complications in nutritional studies of trauma patients. Methods: Retrospective review of serum glucose values in two published randomized, prospective studies of patients receiving either enteral or parenteral feeding (trial 1) or isonitrogenous, isocaloric enteral diets (trial 2). Trial 2 also included patients prospectively followed who received little or no enteral feeding. Results: Patients randomized to enteral or parenteral feeding in trial 1 exhibited no significant differences in the highest recorded serum glucose (SG) until the fourth or fifth day after protocol entry. SG tended to be higher in infected than noninfected patients in the first 4 hospital days, but SG was far below values considered to increase the risk for infection (SG > 220 mg/dL). In trial 2, glucose levels tended to be slightly higher in infected than in noninfected patients within the first 5 days reaching statistical significance by day 5. Unfed control patients had similar SG values but significantly more major infectious complications. Conclusions: Patients developing infections had slightly higher SG levels than noninfected patients early in admission, but these SG values were far below levels considered a risk for infective complications. Significant hyperglycemia does not explain differences in infectious complications in critically ill trauma patients randomized to various routes and types of nutrition. (Journal of Parenteral and Enteral Nutrition 25:174–179, 2001)
• Potassium-graphite as a metalation reagent. Synthesis of aldehydes and ketones by alkylation of imines and dihydro-1,3-oxazine
  作者：Diego Savoia、Claudio Trombini、Achille Umani-Ronchi

  DOI：10.1021/jo00408a034

  日期：1978.7
• Kinetic Resolution of 4-Hydroxy-2-ketones Catalyzed by a Baeyer–Villiger Monooxygenase
  作者：Anett Kirschner、Uwe T. Bornscheuer

  DOI：10.1002/anie.200602986

  日期：2006.10.27
• Highly sensitive and rapid detection of antibody catalysis by luminescent bacteria
  作者：Hagit Shulman、Anatol Eberhard、Carolyn Eberhard、Shimon Ulitzur、Ehud Keinan

  DOI：10.1016/s0960-894x(00)00455-8

  日期：2000.10

  A highly sensitive, inexpensive, and facile bioluminescent assay for the detection of catalytic antibodies has been developed. This assay may be used for the early detection of antibody catalysis. The efficiency of this technique was exemplified by the use of the luminescent bacterium VhM42 for monitoring an antibody-catalyzed retroaldol fragmentation reaction with aldolase antibodies 38C2 and 24H6. (C) 2000 Elsevier Science Ltd. All rights reserved.