(2R)-1-cyclopropylmethyl-2-[3-(3,4-dichlorophenyl)propyl]piperidine | 546113-90-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: (2R)-1-cyclopropylmethyl-2-[3-(3,4-dichlorophenyl)propyl]piperidine
• 英文别名: (2R)-1-(cyclopropylmethyl)-2-[3-(3,4-dichlorophenyl)propyl]piperidine
• CAS: 546113-90-0
• 化学式: C₁₈H₂₅Cl₂N
• 分子量: 326.309
• InChiKey: JMSDZSGOHRDPDS-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• N-(Cyclopropylmethyl)-azacycloalkanes, compositions containing them and methods for their preparation
  申请人：Warner-Lambert Company LLC

  公开号：EP1321461A1

  公开（公告）日：2003-06-25

  The present invention relates to substituted N-(cyclopropylmethyl)azacycloalkanes of the following formula (I): in which, independently, R1 is hydrogen or halogen, R2 is hydrogen or halogen and X is methylene or ethylene, their salts, the pharmaceutical compositions containing them, their use as antidiarrhoeal medicaments and methods for their preparation.

  本发明涉及下式(I)的取代 N-(环丙基甲基)氮杂环烷烃： 其中，R1 独立地为氢或卤素，R2 为氢或卤素，X 为亚甲基或亚乙基，它们的盐、含有它们的药物组合物、它们作为止泻药的用途以及它们的制备方法。
• N-(cyclopropylmethyl)azacycloalkanes, compositions containing them and methods of preparation
  申请人：——

  公开号：US20030139448A1

  公开（公告）日：2003-07-24

  The present invention relates to substituted N-(cyclopropylmethyl)azacycloalkanes of the following formula (I): 1 in which, independently, R 1 is hydrogen or halogen, R 2 is hydrogen or halogen and X is methylene or ethylene, their salts, the pharmaceutical compositions containing them, their use as antidiarrhoeal medicaments and methods for their preparation.

  本发明涉及下式（I）的取代 N-（环丙基甲基）氮杂环烷： 1 其中，R 1 是氢或卤素，R 2 是氢或卤素，X 是亚甲基或亚乙基、它们的盐、含有它们的药物组合物、它们作为止泻药的用途以及它们的制备方法。
• US6787563B2
  申请人：——

  公开号：US6787563B2

  公开（公告）日：2004-09-07