N-(13-pyridin-3-yltridecyl)hydroxylamine | 339169-15-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(13-pyridin-3-yltridecyl)hydroxylamine
• CAS: 339169-15-2
• 化学式: C₁₈H₃₂N₂O
• 分子量: 292.465
• InChiKey: OVLLQQDDKQOMAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Z-14-(pyridin-3-yl)-tetradec-5-en-1-al 、 N-(13-pyridin-3-yltridecyl)hydroxylamine 以 甲苯 为溶剂， 以81%的产率得到pyrinodemin B
  参考文献：
  名称：

  Synthesis of pyrinodemins A and B. Assignment of the double bond position of pyrinodemin A

  摘要：

  Condensation of aldehyde 3a with hydroxylamine 4b afforded nitrone 2, which underwent an intramolecular cycloaddition to give Ib, the proposed structure of pyrinodemin A. A similar condensation of aldehyde 3a and hydroxylamine 4a provided pyrinodemin A (1a), which has the double bond one carbon further away from the isoxazolidine. An analogous sequence gave pyrinodemin B (21). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00003-x
• 作为产物：
  描述：

  11-溴-1-十一醇 在 platinum(IV) oxide copper(l) iodide 、 (PPh₃)2PdCl 、 盐酸羟胺 、 氢气 、 sodium acetate 、 sodium cyanoborohydride 、 sodium iodide 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 二甲基亚砜 为溶剂， -10.0~20.0 ℃ 、101.33 kPa 条件下， 反应 48.0h， 生成 N-(13-pyridin-3-yltridecyl)hydroxylamine
  参考文献：
  名称：

  Synthesis of pyrinodemins A and B. Assignment of the double bond position of pyrinodemin A

  摘要：

  Condensation of aldehyde 3a with hydroxylamine 4b afforded nitrone 2, which underwent an intramolecular cycloaddition to give Ib, the proposed structure of pyrinodemin A. A similar condensation of aldehyde 3a and hydroxylamine 4a provided pyrinodemin A (1a), which has the double bond one carbon further away from the isoxazolidine. An analogous sequence gave pyrinodemin B (21). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00003-x

文献信息

• Synthesis of pyrinodemins A and B. Assignment of the double bond position of pyrinodemin A
  作者：Barry B Snider、Bo Shi

  DOI：10.1016/s0040-4039(01)00003-x

  日期：2001.2

  Condensation of aldehyde 3a with hydroxylamine 4b afforded nitrone 2, which underwent an intramolecular cycloaddition to give Ib, the proposed structure of pyrinodemin A. A similar condensation of aldehyde 3a and hydroxylamine 4a provided pyrinodemin A (1a), which has the double bond one carbon further away from the isoxazolidine. An analogous sequence gave pyrinodemin B (21). (C) 2001 Elsevier Science Ltd. All rights reserved.