N-chloroacetyl-3,5,3',5'-tetraiodo-L-thyronine | 97738-15-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-chloroacetyl-3,5,3',5'-tetraiodo-L-thyronine
• 英文别名: N-Chloracetyl-3,5,3',5'-tetrajod-L-thyronin；N-Chloracetyl-L-thyroxin；Chloracetyl-thyroxin；(2S)-2-[(2-chloroacetyl)amino]-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
• CAS: 97738-15-3
• 化学式: C₁₇H₁₂ClI₄NO₅
• 分子量: 853.357
• InChiKey: ABHIUGGJLRXDJV-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲状腺素 、 氯乙酰氯 在 乙酸乙酯 作用下， 生成 N-chloroacetyl-3,5,3',5'-tetraiodo-L-thyronine
  参考文献：
  名称：

  Flumazenil abolishes midazolam-induced increase in the work of nasal breathing

  摘要：

  Purpose: To evaluate the effects of midazolam sedation followed by flumazenil antagonism on the work of nasal breathing in normal humans.Methods: We measured minute ventilation through the nasal route, respiratory frequency, nasal resistance (R-n) and the work of nasal breathing under three conditions: awake, during midazolam sedation, and after flumazenil antagonism in eight healthy human subjects. A custom-made, partitioned face mask enabled nasal and oral airflow to be measured separately. To calculate R-n and the work of nasal breathing, nasal mask and oropharyngeal pressure was also measured.Results: Total resistive work spent on the upstream segment of the nasal route per minute (W-n) (J.min(-1)) was greater during midazolam sedation (3.6 +/- 2.9) than while awake (1.6 +/- 0.9) and after flumazenil antagonism (1.7 +/- 0.6), respectively (mean +/- SD) (P < 0.05). Total resistive work spent on the upstream segment of nasal breathing (W-n/V-nE) (J.L-1) increased from 0.31 +/- 0.14 to 0.75 +/- 0.61 after midazolam administration (P < 0.05) and decreased to 0.31 +/- 0.10 after flumazenil. Following midazolam administration, a strong correlation was observed between changes in W-n/V-nE and changes in (R-n r = 0.852, P < 0.0001), whereas there was no correlation between changes in W-n and changes in (R-n = 0.159, P = 0.279).Conclusion: The work of breathing spent on the upstream segment of the nasal route increases during midazolam sedation and returns to baseline after flumazenil antagonism.

  DOI：

  10.1007/bf03019871