4β-bromo-3,12-dioxo-5β-cholanoic acid-(24) | 26425-57-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4β-bromo-3,12-dioxo-5β-cholanoic acid-(24)
• 英文别名: 4β-Brom-3,12-dioxo-5β-cholansaeure-(24)
• CAS: 26425-57-0
• 化学式: C₂₄H₃₅BrO₄
• 分子量: 467.443
• InChiKey: TWLVKDHRIDVUBU-VAOMXADKSA-N

物化性质

• 熔点：
  188-190 °C
• 沸点：
  575.2±50.0 °C(Predicted)
• 密度：
  1.293±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.27
• 重原子数：
  29.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  71.44
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4β-bromo-3,12-dioxo-5β-cholanoic acid-(24) 在 chromium(VI) oxide 、 甲醇 、 氢氧化钾 、 乙醚 、 镍 、 溶剂黄146 作用下， 生成 3,12-二氧代-5-beta-胆烷-24-酸
  参考文献：
  名称：

  ?4-3,12-Diketo-cholens�ure und Versuch zur �berf�hrung derselben in 3,12-Diketo-allo-cholans�ure

  摘要：

  DOI：

  10.1002/hlca.193702001142
• 作为产物：
  描述：

  3,12-二氧代-5-beta-胆烷-24-酸 在 溴 、 溶剂黄146 作用下， 生成 4β-bromo-3,12-dioxo-5β-cholanoic acid-(24)
  参考文献：
  名称：

  Activity of GH/IGF-1 axis in burn patients: Comparison with normal subjects and patients with GH deficiency

  摘要：

  The aim of this study was to clarify the activity of GH/IGF-I axis as well as the variations of nutritional parameters following a thermal injury in man. To this goal, in 22 patients with burn [BURN, age (mean SE): 46.5+/-3.4 yr, BMI: 25.0+/-0.8 kg/m(2), % burn surface area: 26.0+/-3.0%, ROI score: 0.22+/-0.1] we evaluated IGF-I, IGF binding protein (IGFBP-3), GH, GH binding protein (GHBP), pre-albumin (pre-A), albumin (A) and transferrin (TRA) levels on days 1, 3, 7, 14 and 28 after intensive care unit (ICU) admission. IGF-I, IGFBP-3, GH and GHBP levels were also assayed basally in 29 normal subjects (Ns) (Ns, age: 47.5+/-2.8 yr, BMI: 22.0+/-1.4 kg/m(2)) and in 34 panhypopituitary patients with severe GH deficiency (GHD, age: 42.7+/-2.5 yr, BMI: 25.6+/-0.8 kg/m(2)). On ICU day 1, IGF-I and IGFBP-3 in BURN were higher than those in GHD (p<0.05 for both, respectively) and lower than those in Ns (p<0.05) while GH levels in BURN did not differ from those in Ns and higher than GHD (p<0.01). In BURN, IGF-I and IGFBP-3 levels showed a progressive decline (p<0.05) with nadir on day 14, when they overlapped those in GHD, and then an increase on day 28, though persisting lower than in Ns, while GH levels did not vary during ICU stay. IGF-I levels were associated neither to burn extension nor to ROI score. On ICU day 1 pre-A, A and TRA levels were similar to those in Ns, but underwent a progressive decrease with nadir on day 7 (p<0.001) for pre-A and TRA, and later, on day 14 (p<0.05) for A; pre-A and TRA but not A showed a rebound increase (p<0.01) on day 14, though persistingly lower than in Ns. In conclusion, our present data firstly show the time course variation of IGF-I levels in burn patients as function of nutritional and hormonal variables. It has to be emphasized that in the most critical phase after burn injuries, IGF-I levels are as low as in hypopituitary patients with severe GHD. The physiological basis which leads to the impairment of this endogenous anabolic drive in this phase is, however, not clear yet. (C)2002, Editrice Kurtis.

  DOI：

  10.1007/bf03343974

文献信息

• Noguchi, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1932, vol. 209, p. 249,251
  作者：Noguchi

  DOI：——

  日期：——