2-[(17,17-dimethyl-6,7,15,16-tetrahydrocyclopenta[a]phenanthren-3-yl)oxy]-N,N-diethylethanamine | 61237-32-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 2-[(17,17-dimethyl-6,7,15,16-tetrahydrocyclopenta[a]phenanthren-3-yl)oxy]-N,N-diethylethanamine
• CAS: 61237-32-9
• 化学式: C₂₅H₃₃NO
• 分子量: 363.543
• InChiKey: OXMZVUCEOAMMED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  7,15,16,17-tetrahydro-3-methoxy-17,17-dimethyl-6H-cyclopenta[ a]phenanthrene 在 吡啶盐酸盐 作用下， 生成 2-[(17,17-dimethyl-6,7,15,16-tetrahydrocyclopenta[a]phenanthren-3-yl)oxy]-N,N-diethylethanamine
  参考文献：
  名称：

  Potential hypolipidemic agents derived from 3-hydroxy-17,17-dimethylgona-1,3,5(10),8,11,13-hexaene

  摘要：

  Numerous aryloxy derivatives containing a lipophilic group have been found to possess hypolipidemic activity. This has prompted the preparation of various derivatives of 3-hydroxy-17,17-dimethylgona-1,3,5(10),8,11,13-hexaene (6a). In 6a the lipophilic biphenyl group is incorporated into the steroid nucleus. A three-step synthesis of 6a from 17beta-methylestradiol methyl ether was developed. The derivatives prepared were tested in rats made hypercholesterolemic with propylthiouracil. Several were found active in this test.

  DOI：

  10.1021/jm00212a008

文献信息

• Potential hypolipidemic agents derived from 3-hydroxy-17,17-dimethylgona-1,3,5(10),8,11,13-hexaene
  作者：Leland J. Chinn、Karlene W. Salamon

  DOI：10.1021/jm00212a008

  日期：1977.2

  Numerous aryloxy derivatives containing a lipophilic group have been found to possess hypolipidemic activity. This has prompted the preparation of various derivatives of 3-hydroxy-17,17-dimethylgona-1,3,5(10),8,11,13-hexaene (6a). In 6a the lipophilic biphenyl group is incorporated into the steroid nucleus. A three-step synthesis of 6a from 17beta-methylestradiol methyl ether was developed. The derivatives prepared were tested in rats made hypercholesterolemic with propylthiouracil. Several were found active in this test.