phenylphosphonate | 16486-11-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenylphosphonate
• 英文别名: dioxido-oxo-phenyl-λ5-phosphane
• CAS: 16486-11-6
• 化学式: C₆H₅O₃P
• 分子量: 156.078
• InChiKey: QLZHNIAADXEJJP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  钴 、 phenylphosphonate 以 水 为溶剂， 生成 cobalt(II) phenylphosphonate monohydrate
  参考文献：
  名称：

  Divalent metal phenylphosphonates and phenylarsonates

  摘要：

  DOI：

  10.1016/s0020-1693(00)95524-5

文献信息

• Method and compositions for identifying anti-HIV therapeutic compounds
  申请人：Arimilli N. Murty

  公开号：US20050239054A1

  公开（公告）日：2005-10-27

  Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

  提供了一种识别具有羧酸酯或膦酸酯基团的抗HIV治疗化合物的方法。可以使用新型酶GS-7340酯水解酶筛选这些化合物的库。还提供了与GS-7340酯水解酶相关的组合物和方法。
• Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds
  申请人：Arimilli N. Murty

  公开号：US20050209197A1

  公开（公告）日：2005-09-22

  Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

  本发明揭示了具有抗HIV蛋白酶活性的膦酸酯取代化合物，可用作治疗剂和其他工业用途。该组合物抑制HIV蛋白酶活性和/或在治疗艾滋病和其他抗病毒感染方面有用，以及在检测HIV蛋白酶的测定中有用。
• Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
  申请人：Arimilli N. Murty

  公开号：US20070010489A1

  公开（公告）日：2007-01-11

  Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

  本发明揭示了具有HIV蛋白酶抑制剂性质的膦酸酯取代化合物，其具有作为治疗剂和其他工业用途的用途。该组合物抑制5型HIV蛋白酶活性和/或在治疗艾滋病和其他抗病毒感染方面具有治疗作用，以及在检测HIV蛋白酶方面的检测中有用。
• Toward Prediction of Magnetic Properties in Layered Vanadyl Phosphonates:  Correlation of Magnetic Exchange with the Hammett σ Parameter
  作者：Jean Le Bideau、Dimitris Papoutsakis、James E. Jackson、Daniel G. Nocera

  DOI：10.1021/ja9624836

  日期：1997.2.1

  The magnetic properties of the layered vanadyl phosphonates (LVPs) VO(O3PC6H4-X).nH2O (X = p-NO2, m-F, p-Cl, p-F, H, p-CH3) have been investigated. In the isostructural n = 1 series (X = p-NO2, m-F, p-F, H), the paramagnetic d(1) vanadyl centers are coupled via the O-P-O pathways of V(OPO)(2)V chair-like subunits. The magnetic properties of these LVPs can be systematically controlled by modification of the P atom's electronic environment via variations of the X group in the aryl pendant. The simple paramagnetism of the LVP featuring the strong electron withdrawing substituent X = p-NO2 gives way to increasing antiferromagnetic coupling between the V-IV centers as the electron-donating ability of X is increased. Consistent with a chair-like V(OPO)(2)V exchange pathway between pairs of vanadyl centers, the temperature-dependent magnetic susceptibility data fit a Bleaney-Bowers dimer model. When the substituent is large, as is the case for the p-Cl and p-CH3 species, a structurally different class of LVPs is obtained, in which n = 1.5. In this case, the contribution of the O-P-O linkage is overwhelmed by the presence of the more direct exchange pathway of vanadyl centers through mu(2)-bridging oxygens of a V(mu(2)-O)(2)V dimer, obviating the effects of electronic variations in Be phosphonate bridge. Our results show that magnetic coupling correlates with a simple measure of electronic perturbation of the exchange pathway in LVPs, implying that such interactions can be tuned using the traditional tools of physical organic chemistry.
• Divalent metal phenylphosphonates and phenylarsonates
  作者：Desmond Cunningham、Patrick J.D. Hennelly、Tony Deeney

  DOI：10.1016/s0020-1693(00)95524-5

  日期：1979.1