聚醚多元醇MN-700 | 510758-36-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 聚醚多元醇MN-700
• 英文名称: 5-oxo-5-(prop-2-yn-1-ylamino)pentanoic acid
• 英文别名: 5-oxo-5-(prop-2-ynylamino)pentanoic acid
• CAS: 510758-36-8
• 化学式: C₈H₁₁NO₃
• 分子量: 169.18
• InChiKey: HNQXOUFTFRIUOY-UHFFFAOYSA-N

物化性质

• 熔点：
  75.5-76.2 °C
• 沸点：
  425.7±30.0 °C(Predicted)
• 密度：
  1.167±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  聚醚多元醇MN-700 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (2,3,4,5,6-Pentafluorophenyl) 6-[[5-oxo-5-(prop-2-ynylamino)pentanoyl]amino]hexanoate
  参考文献：
  名称：

  化合物、缀合物及其用途

  摘要：

  本发明提出了化合物，该化合物具有式(I)和(II)所示结构。本发明还提出了该化合物与药物分子连接的缀合物，以及所述化合物和缀合物的用途，例如在检测和治疗中的用途。

  公开号：

  CN114853828A
• 作为产物：
  描述：

  methyl 5-oxo-5-(prop-2-yn-1-ylamino)pentanoate 在 potassium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 0.5h， 以68%的产率得到聚醚多元醇MN-700
  参考文献：
  名称：

  3-硝基-2-(三氟甲基)-2H-色烯衍生物作为P2Y6受体拮抗剂的结构活性关系

  摘要：

  使用 Sonogashira 反应合成了 G q偶联 P2Y 6受体 (P2Y 6 R) 的已知 3-硝基-2-(三氟甲基)-2 H-色烯拮抗剂3的各种 6-炔基类似物，以取代 6-碘团体。这些类似物在功能测定中进行了测试，该测定包括抑制由天然 P2Y 6 R 激动剂 UDP 引起的表达 P2Y 6 R 的星形细胞瘤细胞中的钙动员。安装了 6-乙炔基和 6-氰基，并且炔烃通过烷基和芳基间隔基延伸。最有效的拮抗剂，IC 50约为 1 µM，被发现为三烷基甲硅烷基乙炔基7和8 （亲和力比参考3高 3-5 倍）、丙-2-炔-1-基氨基甲酸叔丁酯14和p -羧基苯基-乙炔基16衍生物、 3和8表现出对UDP诱导的磷酸肌醇产生的可克服的拮抗作用。其他扩链末端羧酸酯衍生物的效力不如相应的甲酯衍生物。因此，该色烯系列中的 6 位适合具有取代灵活性的衍生化，即使是空间延伸的链，也不会损失 P2Y 6 R

  DOI：

  10.1016/j.bmcl.2021.128008

文献信息

• para-Hydrogenation of unsaturated moieties on poly(lysine) derived substrates for the development of novel hyperpolarized MRI contrast agents
  作者：Silvio Aime、Walter Dastrù、Roberto Gobetto、Alessandra Viale

  DOI：10.1039/b510693a

  日期：——

  unsaturation from the poly(lysine) backbone, the more intense the polarized signals when para-hydrogenation is carried out. This is due to (a) the maintenance of short reorientational times on the unsaturated ends, and therefore a sufficiently long T(1) of the protons added during hydrogenation, and (b) the minor effect of steric hindrance by the poly(lysine) backbone that decreases interaction of the

  合成了四种炔官能化的聚赖氨酸衍生物，并通过1H和13C NMR光谱进行了表征。在第一聚（赖氨酸）衍生物中，丙炔酸苯基部分直接结合到胺基臂上，而在其他衍生物中，炔丙基胺部分分别通过葡糖二酸和二甘醇（DG）链结合到胺基聚（赖氨酸）上。对炔基官能化的聚赖氨酸化合物的对氢加氢进行了研究，并就氢化产物的自旋晶格弛豫特性对结果进行了讨论。结果表明，将不饱和键与聚（赖氨酸）骨架分开的移动链越长，进行对位氢化时的极化信号越强。
• Living copolymer-protein/peptide hybrids for biomedical applications
  申请人：Raja Krishnaswami

  公开号：US09242010B2

  公开（公告）日：2016-01-26

  Water soluble polymers having formula I: Y-(L1)n1-(C(O))n2—(R1)n3—R2 are claimed. The polymers may contain multiple water soluble, immunogenicity reducing moieties and multiple active moieties. The polymers may be linked to a protein, or a peptide having up to twelve amino acids.

  具有以下公式的水溶性聚合物被声明：Y-(L1)n1-(C(O))n2—(R1)n3—R2。这些聚合物可能包含多个水溶性、免疫原性降低的基团和多个活性基团。这些聚合物可能与蛋白质或含有最多十二个氨基酸的肽链相连接。
• Living Copolymer-Protein/Peptide Hybrids for Biomedical Applications
  申请人：Raja Krishnaswami

  公开号：US20110262991A1

  公开（公告）日：2011-10-27

  Water soluble polymers having formula I: Y-(L 1 ) ni -(C(O)) n2 —(R 1 ) n3 —R 2 are claimed. The polymers may contain multiple water soluble, immunogenicity reducing moieties and multiple active moieties. The polymers may be linked to a protein, or a peptide having up to twelve amino acids.

  具有I式的水溶性聚合物：Y-(L1)ni-(C（O）)n2—（R1）n3—R2被声明。这些聚合物可以包含多个水溶性、免疫原性降低的基团和多个活性基团。这些聚合物可以与具有多达十二个氨基酸的蛋白质或肽连接。
• Efficient Synthesis of a Water-Soluble Glucoamide Inhibitor Against Human Aldose Reductase by Click Chemistry
  作者：Mikio Fujii、Shinji Sudo、Yasuyuki Kitagawa、Keisuke Kato

  DOI：10.1080/07328303.2013.816852

  日期：2013.9.2

  While D-glucose is the natural substrate of aldose reductase (AR) in the polyol pathway, the K-m value of D-glucose against AR is large. A glucoamide 1 was designed as a tool to investigate whether AR has a strong affinity for the open form of D-glucose. Glucoamide 1 was synthesized in high yield by modification of the reaction condition for click chemistry. It was found that our modified condition was applicable for highly polar alkynes and gave coupling products in excellent yield (90% to 100%). Although weak inhibitory activity against AR was observed, kinetic studies showed that AR does not accept glucoamide 1 in its active site.
• A fluorogenic ‘click’ reaction of azidoanthracene derivatives
  作者：Fang Xie、Krishnamoorthy Sivakumar、Qingbing Zeng、Michael A. Bruckman、Blake Hodges、Qian Wang

  DOI：10.1016/j.tet.2008.01.080

  日期：2008.3

  Fluorogenic reactions have broad applications in biolabeling, combinatorial synthesis of fluorescent dyes, and materials development. It was recently reported that the highly selective and efficient Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction can be employed in designing new types of fluorogenic reactions. In this study, we report a fluorogenic reaction using anthracene azides as starting materials. The fluorescence of the anthryl core can be greatly inhibited upon introducing electron-donating azido groups in the proximity. Such weakly fluorescent anthracene azides demonstrate high reactivity with a variety of alkynes under the CuAAC conditions producing a strongly fluorescent triazole product with high quantum yields. This reaction can be used in the synthesis and screening of fluorescent dyes combinatorially. Compared with most existing methods, the fluorogenic CuAAC reaction is a much milder and simpler technique to prepare large libraries of fluorescent dyes without further purification. In order to demonstrate the efficiency of using anthracene azides for biolabeling applications, both small molecules and biomolecules including the multialkyne-derivatized cowpea mosaic virus and tobacco mosaic virus had been studied. (C) 2008 Elsevier Ltd. All rights reserved.