DL-Valyl-L-Histidin | 13589-07-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DL-Valyl-L-Histidin
• 英文别名: 2-[(2-azaniumyl-3-methylbutanoyl)amino]-3-(1H-imidazol-5-yl)propanoate
• CAS: 13589-07-6；51077-04-4；51077-05-5；51077-07-7；51077-08-8；51077-09-9；51077-10-2；51077-11-3
• 化学式: C₁₁H₁₈N₄O₃
• 分子量: 254.289
• InChiKey: BNQVUHQWZGTIBX-UHFFFAOYSA-N

物化性质

• 熔点：
  >192°C (dec.)
• 溶解度：
  可溶于甲醇，水

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 海关编码：
  2933290090

文献信息

• Novel fructosyl peptide oxidase and utilization thereof
  申请人：Ebinuma Hiroyuki

  公开号：US20070054344A1

  公开（公告）日：2007-03-08

  The present invention is directed to a defructosylation enzyme originating from a plant, a method of defructosylating a fructosylated peptide or protein through use of the enzyme, and a method of measuring a fructosylated peptide or protein.

  本发明涉及一种来自植物的去果糖化酶，一种通过使用该酶去除果糖化肽或蛋白质的方法，以及一种测量果糖化肽或蛋白质的方法。
• METHOD OF ASSAYING GLYCOPROTEIN
  申请人：KIKKOMAN CORPORATION

  公开号：EP1223224A1

  公开（公告）日：2002-07-17

  Based on a principle that is different to that of a conventional enzymatic method, the present invention provides a novel method for assaying a glycated protein by a simple procedure, within a short period of time, and with high accuracy, and a reagent kit for assaying used in the method. The method for assaying a glycated protein in a sample is realized by treating a glycated protein-containing sample with protease to liberate a glycated peptide, preferably an α-glycated peptide, particularly preferably an α-glycated dipeptide, from a glycated protein, allowing an oxidase to react with the liberated glycated peptide, and determining the produced hydrogen peroxide.

  根据不同于传统酶法的原理，本发明提供了一种程序简单、时间短、准确度高的新型糖化蛋白检测方法，以及用于该方法的检测试剂盒。检测样品中糖化蛋白质的方法是这样实现的：用蛋白酶处理含糖化蛋白质的样品，从糖化蛋白质中释放出糖化肽，最好是α-糖化肽，特别是α-糖化二肽，让氧化酶与释放出的糖化肽反应，测定产生的过氧化氢。
• Fructosyl peptide oxidase
  申请人：KIKKOMAN CORPORATION

  公开号：EP1291416A1

  公开（公告）日：2003-03-12

  The present invention has an object of providing a novel fructosyl peptide oxidase having superior physicochemical properties such as stability that is useful as an enzyme for clinical diagnosis, and an object of providing a method for producing the fructosyl peptide oxidase. A novel fructosyl peptide oxidase having physicochemical properties useful as an enzyme for clinical diagnosis, and a method for producing a novel fructosyl peptide oxidase are provided herein, the method comprising: culturing a microorganism capable of producing the oxidase in a medium; and collecting the oxidase from the culture. Furthermore, a fructosyl peptide oxidase gene coding for a novel fructosyl peptide oxidase, recombinant DNA wherein the gene is inserted into vector DNA, and a method for producing a novel fructosyl peptide oxidase are provided herein, the method comprising: culturing, in a medium, a transformant or a transductant including the gene; and collecting the novel fructosyl peptide oxidase from the culture.

  本发明的目的是提供一种新型果糖基肽氧化酶，它具有优异的理化性质，如稳定性，可作为一种酶用于临床诊断，本发明的目的还包括提供一种生产果糖基肽氧化酶的方法。 本文提供了一种新型果糖基肽氧化酶，其理化性质可用作临床诊断用酶，还提供了一种生产新型果糖基肽氧化酶的方法，该方法包括：在培养基中培养能够产生氧化酶的微生物；从培养物中收集氧化酶。此外，本文还提供了编码新型果糖基肽氧化酶的果糖基肽氧化酶基因、将该基因插入载体 DNA 的重组 DNA 以及生产新型果糖基肽氧化酶的方法，该方法包括：在培养基中培养包括该基因的转化体或转导体；以及从培养物中收集新型果糖基肽氧化酶。
• PROCESS FOR PRODUCING a-GLYCOSYLATED DIPEPTIDE AND METHOD OF ASSAYING a-GLYCOSYLATED DIPEPTIDE
  申请人：KIKKOMAN CORPORATION

  公开号：EP1679378A1

  公开（公告）日：2006-07-12

  The present invention relates to a method for producing α-glycated dipeptide, which comprises causing protease to act on N-terminal-glycated peptide or N-terminal-glycated protein. The present invention further relates to a method for determining the amount of α-glycated dipeptide, which comprises causing a fructosyl peptide oxidase to act on the α-glycated dipeptide obtained by the above method and then determining the amount of the thus generated hydrogen peroxide. According to the present invention, a method for producing α-glycated dipeptide is provided, which enables the simple, rapid, and efficient production of α-glycated dipeptide from glycated protein or glycated peptide. Furthermore, according to the present invention, a method for determining the amount of α-glycated dipeptide is provided, which enables to determine the amount of α-glycated dipeptide in a highly precise manner within a short time period.

  本发明涉及一种生产α-糖化二肽的方法，它包括使蛋白酶作用于N-末端糖化的肽或N-末端糖化的蛋白质。本发明还涉及一种测定α-糖化二肽量的方法，该方法包括使果糖基肽氧化酶作用于通过上述方法获得的α-糖化二肽，然后测定由此产生的过氧化氢的量。根据本发明，提供了一种生产α-糖化二肽的方法，该方法能够从糖化蛋白质或糖化肽中简单、快速、高效地生产α-糖化二肽。此外，根据本发明，还提供了一种测定α-糖化二肽量的方法，该方法能够在短时间内以高度精确的方式测定α-糖化二肽的量。
• METHOD OF ASSYAING GLYCOPROTEIN
  申请人：DAIICHI PURE CHEMICALS CO., LTD.

  公开号：EP1693461A1

  公开（公告）日：2006-08-23

  The present invention provides a convenient, efficient method for assaying glycated protein, fructosyl peptide, or fructosyl amino acid which can be performed with reduced effect of fructosyl lysine compounds. The invention also provides a reagent for the assay. The invention is directed to a method for reducing the effect of a fructosyl lysine compound in an assay of fructosyl peptide or fructosyl amino acid contained in a sample, characterized by including causing an enzyme for assaying fructosyl peptide or fructosyl amino acid to act specifically on fructosyl peptide or fructosyl amino acid at a pH of 4.0 to 7.0 and measuring the product at a pH of 4.0 to 7.0; and a method for assaying glycated protein through the above method.

  本发明提供了一种测定糖化蛋白质、果糖基肽或果糖基氨基酸的方便、高效的方法，该方法可在降低果糖基赖氨酸化合物影响的情况下进行。本发明还提供了一种用于检测的试剂。 本发明涉及一种在检测样品中所含的果糖基肽或果糖基氨基酸时减少果糖基赖氨酸化合物影响的方法，其特征在于包括使检测果糖基肽或果糖基氨基酸的酶在 pH 值为 4.0至7.0的pH值下特异性地作用于果糖基肽或果糖基氨基酸，并在4.0至7.0的pH值下测定产物；以及通过上述方法测定糖化蛋白质的方法。