5R,9R,13R,14S-oxycodone acetylsalicylate | 956970-00-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 5R,9R,13R,14S-oxycodone acetylsalicylate
• 英文别名: Aspirin and oxycodone；(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;2-acetyloxybenzoic acid
• CAS: 956970-00-6
• 化学式: C₉H₈O₄*C₁₈H₂₁NO₄
• 分子量: 495.529
• InChiKey: SOVLIWPQFCJTTO-RKXJKUSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.36
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  盐酸羟可待酮 、 阿司匹林 在 氢氧化钾 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 生成 5R,9R,13R,14S-oxycodone acetylsalicylate
  参考文献：
  名称：

  Narcotic-NSAID ion pairs

  摘要：

  本发明提供了一种公式为[narcotic]+[A]−的离子对化合物，其中[narcotic]+代表至少一个麻醉剂或其一个或多个立体化学异构体的至少一个阳离子，而[A]−代表至少一个非甾体抗炎药（NSAID）或其一个或多个立体化学异构体的至少一个阴离子。离子对化合物的一个例子是丙氧芬双氯芬酸。这些离子对化合物或其药物组合物在治疗表明需要镇痛剂、抗炎剂或两者都需要的方法中是有用的。在规定的使用条件下，离子对化合物在低pH环境中表现出较差或完全不溶性，但在胃中这类环境中却具有极佳的化学稳定性。离子对化合物在较高pH值的环境中，如小肠，能够快速溶解和离解，以释放组成的麻醉剂和非甾体抗炎药。

  公开号：

  US20050203115A1

文献信息

• TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A POWDER
  申请人：Grünenthal GmbH

  公开号：EP3285746A1

  公开（公告）日：2018-02-28
• PROTECTING ORAL OVERDOSE WITH ABUSE DETERRENT IMMEDIATE RELEASE FORMULATIONS
  申请人：Grünenthal GmbH

  公开号：EP3346991A1

  公开（公告）日：2018-07-18
• [EN] NARCOTIC-NSAID ION PAIRS<br/>[FR] PAIRS D'IONS NARCOTIQUE/AINS
  申请人：AAIPHARMA INC

  公开号：WO2005086960A2

  公开（公告）日：2005-09-22

  The present invention provides an ion pair compound of the formula [narcotic]+[A]-, wherein [narcotic]+ represents at least one cation of at least one narcotic agent or one or more stereochemical isomers thereof and [A]- represents at least one anion of at least one NSAID or one or more stereochemical isomers thereof. An example of the ion pair compound is propoxyphene diclofenate. The ion pair compounds, or their pharmaceutical compositions, are useful in methods of treating a wide variety of conditions that indicate analgesics, anti-inflammatory agents, or both. Under the conditions prescribed for their use, the ion pair compounds exhibit poor or complete insolubility but excellent chemical stability in low pH environments, such as those found in the stomach. The ion pair compounds readily dissolve and dissociate in higher pH environments such as the small intestine to release the constituent narcotic and NSAID.
• [EN] TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A POWDER<br/>[FR] COMBINAISON DE DOSE FIXE INVIOLABLE PERMETTANT LA LIBÉRATION RAPIDE DE DEUX MÉDICAMENTS À PARTIR DE PARTICULES ET D'UNE POUDRE
  申请人：GRUENENTHAL GMBH

  公开号：WO2016170095A1

  公开（公告）日：2016-10-27

  The invention relates to a tamper -resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form according to the invention is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.
• [EN] PROTECTING ORAL OVERDOSE WITH ABUSE DETERRENT IMMEDIATE RELEASE FORMULATIONS<br/>[FR] PROTECTION CONTRE UN SURDOSAGE PAR VOIE ORALE À L'AIDE DE FORMULATIONS À LIBÉRATION IMMÉDIATE DISSUASIVES D'ABUS
  申请人：GRUENENTHAL GMBH

  公开号：WO2017042325A1

  公开（公告）日：2017-03-16

  The invention relates to a pharmaceutical dosage form which is particularly useful for the prevention of an overdose of the pharmacologically active ingredient contained therein after accidental or intentional simultaneous administration of a plurality of the dosage forms containing an overall supratherapeutic dose of the pharmacologically active ingredient.