dioctyl(N-octylaminomethyl)phosphine oxide | 876930-56-2

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: dioctyl(N-octylaminomethyl)phosphine oxide
• 英文别名: (N-octylaminomethyl)dioctylphosphine oxide；N-(dioctylphosphorylmethyl)octan-1-amine
• CAS: 876930-56-2
• 化学式: C₂₅H₅₄NOP
• 分子量: 415.684
• InChiKey: OMTWTYGXEHGQRF-UHFFFAOYSA-N

物化性质

• 熔点：
  48 °C
• 沸点：
  532.9±33.0 °C(Predicted)
• 密度：
  0.876±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  28
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dioctyl(N-octylaminomethyl)phosphine oxide 、 dihexylphosphinous acid 、 三聚乙醛 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 以50%的产率得到dihexyl[[N-octyl-N-(dihexylphosphinoylmethyl)amino]methyl]phosphine oxide
  参考文献：
  名称：

  Synthesis of novel mono-and bisaminophosphoryl compounds and their membrane transport properties for acidic substrates

  摘要：

  Some novel aminophosphoryl compounds were synthesized by the Kabachnik-Fields reaction. Their membrane transport properties for mono-and polyfunctional carboxylic acids with different number of functional groups were studied to establish that the transport rate of acidic substrates through liquid impregnated membranes increases in going from mono-to diphosphoryl carriers. Additional hydrophilic groups in the substrate molecule, too, affect transport efficiency.

  DOI：

  10.1134/s1070363208070062
• 作为产物：
  描述：

  辛胺 、 Dioctylphosphinigsaeure 、 三聚乙醛 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 以80%的产率得到dioctyl(N-octylaminomethyl)phosphine oxide
  参考文献：
  名称：

  Synthesis of novel mono-and bisaminophosphoryl compounds and their membrane transport properties for acidic substrates

  摘要：

  Some novel aminophosphoryl compounds were synthesized by the Kabachnik-Fields reaction. Their membrane transport properties for mono-and polyfunctional carboxylic acids with different number of functional groups were studied to establish that the transport rate of acidic substrates through liquid impregnated membranes increases in going from mono-to diphosphoryl carriers. Additional hydrophilic groups in the substrate molecule, too, affect transport efficiency.

  DOI：

  10.1134/s1070363208070062

文献信息

• Synthesis of new liophilic functionalized aminomethylphosphine oxides and their acid-base and membrane-transport properties toward acidic substrates
  作者：R. A. Cherkasov、A. R. Garifzyanov、A. S. Talan、R. R. Davletshin、N. V. Kurnosova

  DOI：10.1134/s1070363209090114

  日期：2009.9

  A large number of new lipophilic mono- and bisphosphinylamines including those possessing additional potential centers of coordination was synthesized on the basis of the Kabachnik-Fields reaction, and acid-base and membrane transport properties of the synthesized compounds toward the mono- and polybasic carboxylic acids were studied. By their basicity all the synthesized aminophosphine oxides were

  在Kabachnik-Fields反应的基础上，合成了许多新的亲脂性单膦酸和双膦胺，包括具有额外潜在配位中心的那些，以及合成的化合物对一元和多元羧酸的酸碱和膜传输特性被研究了。由于它们的碱性，所有合成的氨基膦氧化物均显示出劣于其脂族胺前体。第二次膦基的引入极大地降低了碱性，以致于不可能通过电位法确定p K a。讨论了氨基次膦酰基载体与底物的结构与酸性底物的膜运输效率之间的相互关系。