2-(1-methyl-4-nitropyrrol-2-yl)-1H-imidazo[4,5-b]pyridine | 682748-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-(1-methyl-4-nitropyrrol-2-yl)-1H-imidazo[4,5-b]pyridine
• CAS: 682748-66-9
• 化学式: C₁₁H₉N₅O₂
• 分子量: 243.225
• InChiKey: QPCAKISFPZCKNO-UHFFFAOYSA-N

物化性质

• 沸点：
  512.9±60.0 °C(Predicted)
• 密度：
  1.58±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.87
• 重原子数：
  18.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  89.64
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-(1-methyl-4-nitropyrrol-2-yl)-1H-imidazo[4,5-b]pyridine 在 palladium on activated charcoal 氢气 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 25.0~37.0 ℃ 、101.33 kPa 条件下， 反应 16.0h， 生成 Isoquinoline-3-carboxylic acid {1-(3-dimethylamino-propyl)-5-[5-(3H-imidazo[4,5-b]pyridin-2-yl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1H-pyrrol-3-yl}-amide
  参考文献：
  名称：

  DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives

  摘要：

  The synthesis and in vitro potency of DNA minor-groove binding antibacterials lacking the C-terminal amide bond are described. The crescent shaped molecules bear the positively charged amino group at an internal pyrrole unit instead of the C-terminus. Three structural parameters were investigated: the N-terminal unit, the internal amino group, and the C-terminal ring system. Several compounds demonstrated good in vitro potency against various Gram-positive bacteria and some molecules were moderately active against Escherichia coli, a representative Gram-negative strain. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.043
• 作为产物：
  描述：

  1-甲基-4-硝基吡咯-2-羧酸 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 溶剂黄146 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 31.0h， 生成 2-(1-methyl-4-nitropyrrol-2-yl)-1H-imidazo[4,5-b]pyridine
  参考文献：
  名称：

  DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives

  摘要：

  The synthesis and in vitro potency of DNA minor-groove binding antibacterials lacking the C-terminal amide bond are described. The crescent shaped molecules bear the positively charged amino group at an internal pyrrole unit instead of the C-terminus. Three structural parameters were investigated: the N-terminal unit, the internal amino group, and the C-terminal ring system. Several compounds demonstrated good in vitro potency against various Gram-positive bacteria and some molecules were moderately active against Escherichia coli, a representative Gram-negative strain. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.043