trans-[Cu(propronalol)2] | 1198567-01-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: trans-[Cu(propronalol)2]
• CAS: 1198567-01-9
• 化学式: C₃₂H₄₀CuN₂O₄
• 分子量: 580.227
• InChiKey: LOKOYUDEVYJFMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  trans-[Cu(propronalol)2]*2H2O 以 neat (no solvent) 为溶剂， 生成 trans-[Cu(propronalol)2]
  参考文献：
  名称：

  Synthesis, structural characterization and ex vivo biological properties of a new complex [Cu(propranolol)2]·2H2O, a potential beta-blocker

  摘要：

  The synthesis and spectroscopic characterization (UV-Vis, IR, EPR) of a new copper complex with a beta-blocker propranolol (1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol) are presented. Besides, the X-ray crystal structure of [Cu(propranolol)(2)]center dot 2H(2)O is determined, showing two different copper ions, one coordinated through two S propranolol isomers and the other through two R isomers. The effect on the heart contraction force and on the heart rate plus the block of response to adrenaline of the complex and the free ligand, were studied. The effect of [Cu(propranolol)(2)]center dot 2H(2)O on contractility was very similar to that of the free propranolol while the reduction on the heart rate is approximately 30% of the reduction obtained with the free ligand. This is an encouraging result since the search of new beta-blocker drugs that have lesser effect on heart rate is one of the important topics in cardiac pharmacology. The block of the response to adrenaline is at least similar for both ligand and complex. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2009.07.064