AADB96611-28A | 93140-61-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: AADB96611-28A
• 英文别名: 67211x21；4-(2,4,6-Trimethoxy-phenyl)-2,3-dichlor-Δ^2,3-crotonlacton；3,4-dichloro-5-(2,4,6-trimethoxy-phenyl)-5H-furan-2-one；3,4-Dichloro-5-(2,4,6-trimethoxyphenyl)furan-2(5H)-one；3,4-dichloro-2-(2,4,6-trimethoxyphenyl)-2H-furan-5-one
• CAS: 93140-61-5
• 化学式: C₁₃H₁₂Cl₂O₅
• 分子量: 319.141
• InChiKey: GZBVYYOCDZCJFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,4-二氯-5-羟基-5H-呋喃-2-酮 、 1,3,5-三甲氧基苯 在 硫酸 作用下， 以 溶剂黄146 为溶剂， 反应 0.5h， 以98%的产率得到AADB96611-28A
  参考文献：
  名称：

  Lewis and Brönsted acid catalyzed Friedel–Crafts hydroxyalkylation of mucohalic acids: a facile synthesis of functionalized γ-aryl γ-butenolides

  摘要：

  A catalytic, green and practical method for Friedel-Crafts hydroxyalkylation of mucohalic acid has been accomplished. Reaction of mucohalic acids with various electron-rich aromatic compounds in the presence of catalytic (1 mol % to 10 mol %) In(OTf)(3) or Bronsted acid, such as H2SO4 in acetic acid provides gamma-aryl gamma-butenolides in moderate to excellent yield. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.02.009

文献信息

• Lewis and Brönsted acid catalyzed Friedel–Crafts hydroxyalkylation of mucohalic acids: a facile synthesis of functionalized γ-aryl γ-butenolides
  作者：Ji Zhang、Peter G. Blazecka、Timothy T. Curran

  DOI：10.1016/j.tetlet.2007.02.009

  日期：2007.4

  A catalytic, green and practical method for Friedel-Crafts hydroxyalkylation of mucohalic acid has been accomplished. Reaction of mucohalic acids with various electron-rich aromatic compounds in the presence of catalytic (1 mol % to 10 mol %) In(OTf)(3) or Bronsted acid, such as H2SO4 in acetic acid provides gamma-aryl gamma-butenolides in moderate to excellent yield. (c) 2007 Elsevier Ltd. All rights reserved.