2-Methoxy-4-[(4-morpholin-4-ylanilino)methylidene]cyclohexa-2,5-dien-1-one | 7144-84-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-Methoxy-4-[(4-morpholin-4-ylanilino)methylidene]cyclohexa-2,5-dien-1-one
• 英文别名: 2-methoxy-4-[(4-morpholin-4-ylphenyl)iminomethyl]phenol
• CAS: 7144-84-5
• 化学式: C₁₈H₂₀N₂O₃
• 分子量: 312.368
• InChiKey: DGTCGNJDVGWKPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  54.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(4-吗啉基)苯胺 、 香草醛 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以75%的产率得到2-Methoxy-4-[(4-morpholin-4-ylanilino)methylidene]cyclohexa-2,5-dien-1-one
  参考文献：
  名称：

  Synthesis of Schiff bases of 4-(4-aminophenyl)-morpholine as potential antimicrobial agents

  摘要：

  In the present study, a novel series of Schiff bases of 4-(4-aminophenyl)-morpholinewere synthesised and characterised by IR, H-1-NMR, C-13-NMR, Mass spectral and elemental analysis. The compounds were screened for antibacterial (Staphylococcus aureus (ATCC 9144), Staphylococcus epidermidis (ATCC 155), Bacillus cereus (ATCC 11778), Micrococcus luteus (ATCC 4678), and Escherichia coli (ATCC 25922)) and antifungal (Candida albicans (ATCC 2091) and Aspergillus niger (ATCC 9029)) activities. The minimum inhibitory concentrations of the compounds were also ascertained by agar streak dilution method. 4-(4-(4-Hydroxy-benzylidene-imino)phenyl)-morpholine (7) was found to be the most potent antimicrobial activity with MIC of 25, 19, 21, 16, 29, 20 and 40 mug/ml against S. aureus, S. epidermidis, B, cereus, M. luteus, E. coli, C albicans and A. niger, respectively. All the other compounds exhibited moderate activity against the bacterial and fungal organisms tested. (C) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.09.003