Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, method of inhibiting a Beta-lactamase enzyme by administering said compounds, processes for preparing the compounds and new intermediates useful in the process are disclosed.
本发明涉及一般式为##
STR1##的
碳青霉
烯类
抗生素化合物,其中基团##
STR2##是4、5或6成员的单、二或三取代
氧或
硫含环;其中Z是
氧、
硫、
亚砜和磺酰基,所述药物组成物对治疗细菌感染有用,通过给予所述化合物抑制β-内
酰胺酶酶的方法,揭示了制备该化合物的过程以及在该过程中有用的新
中间体。