[Ag2(saccharinate)2(μ-1,1-bis(diphenylphosphino)methane)H2O]*H2O | 1473399-44-8

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: [Ag2(saccharinate)2(μ-1,1-bis(diphenylphosphino)methane)H2O]*H2O
• 英文别名: [Ag₂(saccharinate)₂(μ-1,1-bis(diphenylphosphino)methane)H₂O]*H₂O；[Ag₂(sac)₂(μ-dppm)H₂O]*H₂O
• CAS: 1473399-44-8
• 化学式: C₃₉H₃₂Ag₂N₂O₇P₂S₂*H₂O
• 分子量: 1000.52
• InChiKey: XLHNHHCLBPZDPI-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  sodium saccharinate dihydrate 、 silver nitrate 、 双二苯基膦甲烷 以 甲醇 、 乙腈 为溶剂， 反应 2.5h， 以72%的产率得到[Ag2(saccharinate)2(μ-1,1-bis(diphenylphosphino)methane)H2O]*H2O
  参考文献：
  名称：

  Di- and polynuclear silver(I) saccharinate complexes of tertiary diphosphane ligands: synthesis, structures, in vitro DNA binding, and antibacterial and anticancer properties

  摘要：

  A series of new silver(I) saccharinate (sac) complexes, [Ag-2(sac)(2)(mu-dppm)H2O]center dot H2O (1), {[Ag-2(mu-sac)(2)(mu-dppe)]center dot 3H(2)O center dot CH2Cl2} (n) (2), [Ag-2(mu-sac)(2)(mu-dppp)] (n) (3), and [Ag(sac)(mu-dppb)] (n) (4) [dppm is 1,1-bis(diphenylphosphino)methane, dppe is 1,2-bis(diphenylphosphino)ethane, dppp is 1,3-bis(diphenylphosphino)propane, and dppb is 1,4-bis(diphenylphosphino)butane], have been synthesized and characterized by C, H, N elemental analysis, IR spectroscopy, H-1 NMR, C-13 NMR, and P-31 NMR spectroscopy, electrospray ionization mass spectrometry, and thermogravimetry-differential thermal analysis. Single-crystal X-ray studies show that the diphosphanes act as bridging ligands to yield a dinuclear complex (1) and one-dimensional coordination polymers (2 and 4), whereas the sac ligand adopts a mu(2)-N/O bridging mode in 2, and is N-coordinated in 1 and 4. The interaction of the silver(I) complexes with fish sperm DNA was investigated using UV-vis spectroscopy, fluorescence spectroscopy, and agarose gel electrophoresis. The binding studies indicate that the silver(I) complexes can interact with fish sperm DNA through intercalation, and complexes 1 and 3 have the highest binding affinity. The gel electrophoresis assay further confirms the binding of the complexes with the pBR322 plasmid DNA. The minimum inhibitory concentrations of the complexes indicate that complex 1 exhibits very high antibacterial activity against standard bacterial strains of Escherichia coli, Salmonella typhimurium, and Staphylococcus aureus, being much higher than those of AgNO3, silver sulfadiazine, ciprofloxacin, and gentamicin. Moreover, complexes 1-3 exhibit very high cytotoxic activity against A549 and MCF-7 cancer cell lines, compared with AgNO3 and cisplatin. The bacterial and cell growth inhibitions of the silver(I) complexes are closely related to their DNA binding affinities.

  DOI：

  10.1007/s00775-013-1052-y