N,N-dihydroxypyridine-1,3-dicarboximidoyl dichloride | 65823-19-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N-dihydroxypyridine-1,3-dicarboximidoyl dichloride
• 英文别名: N,N-dihydroxypyridine-2,6-dicarboximidoyl dichloride；N,N'-dihydroxy-pyridine-2,6-dicarboximidoyl dichloride；pyridine-2,6-dihydroxamic acid dichloride
• CAS: 65823-19-0
• 化学式: C₇H₅Cl₂N₃O₂
• 分子量: 234.042
• InChiKey: JLQKYKFDVPEYET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.83
• 重原子数：
  14.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.07
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  N,N-dihydroxypyridine-1,3-dicarboximidoyl dichloride 在 氢氧化钾 作用下， 以 乙醚 为溶剂， 生成 6,6'-(2-oxy-furazan-3,4-diyl)-bis-pyridine-2-carbaldehyde dioxime
  参考文献：
  名称：

  Pyridineazidoximes and Furoxans¹

  摘要：

  DOI：

  10.1021/jo01044a025
• 作为产物：
  描述：

  吡啶-2,6-二甲醛二肟 在 N-氯代丁二酰亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 以69%的产率得到N,N-dihydroxypyridine-1,3-dicarboximidoyl dichloride
  参考文献：
  名称：

  多重环加成大环化：冠醚型环烷、双杯[4]芳烃和硅大环化合物的有效方法

  摘要：

  大环化合物构成了广泛的一类化合物，在主客体超分子化学中发挥着重要作用。我们合理设计了一种高效的新型合成方法，用于合成含有异噁唑啉或异噁唑环系的人工受体大环。该方法涉及双功能亲电试剂与双功能亲双烯体之间的多次（双、三或四重）环加成反应。我们展示了合成结果，表明这种一锅法合成方法可以轻松扩展，用于合成不同类型的大环，如环芳烷、双杯[4]芳烃和大环硅烷。因此，通过适当组合双功能亲双烯体和双功能亲电试剂，可以控制大环的环尺寸。这种多次环加成大环化将为合成各种大环提供有用的工具。

  DOI：

  10.1055/s-2001-18061

文献信息

• 1-aziridino-1-hydroxyiminomethyl-derivates, method for the production thereof and medicaments containing said compounds
  申请人：——

  公开号：US07078418B1

  公开（公告）日：2006-07-18

  Described are new 1-aziridino-1-hydroxyiminomethyl derivatives with the general formula (I), wherein R is able to is a single bond or a linker moiety capable of covalently bonding two aziridine oxime groups, R1 and R2 independently of one another are selected from the group consisting of —H, —CH3, —C2H5, —CN, —COOH, —COOCH3, —COOC2H5, —CONH2, or —C6H5 group, and n is the whole number 2, provided that R1 and R2 are not both —H and provided that R1 is not —H if R2 is —CH3 and R1 is not —CH3 if R2 is —H The compounds of general formula (I) show antitumor activity.

  描述了具有一般式(I)的新的1-氮杂环丙烯基-1-羟亚胺甲基衍生物，其中R能够是单键或能够共价结合两个环丙烯基肟基团的连接基团，R1和R2分别独立地选自包括—H、—CH3、—C2H5、—CN、—COOH、—COO 、—COO 、—CONH2或—C6H5基团的群，n是整数2，前提是R1和R2不同时为—H，并且如果R2为— ，则R1不是—H，如果R2为—H，则R1不是— 。一般式(I)的化合物表现出抗肿瘤活性。
• Novel silicon-bridged macrocycles: efficient synthesis by quadruple cycloadditive macrocyclization and intramolecular nitrile oxide dimerization
  作者：Chan Woo Lee、Gil Tae Hwang、Byeang Hyean Kim

  DOI：10.1016/s0040-4039(00)00599-2

  日期：2000.5

  Novel silacyclophanes have been synthesized by using quadruple cycloadditive macrocyclization and intramolecular nitrile oxide dimerization. The macrocyclic cycloadducts were characterized by spectroscopic methods and X-ray crystallography.

  通过使用四重环加成的大环化和分子内的一氧化二氮二聚合成了新型的硅杂环烷。通过光谱法和X射线晶体学对大环环加合物进行了表征。
• Crown Ether-Type Cyclophanes: Efficient Synthesis via Quadruple or Double Cycloadditions and Molecular Recognition Study
  作者：Byeang Hyean Kim、Eun Jeong Jeong、Won Hee Jung

  DOI：10.1021/ja00128a042

  日期：1995.6
• Carbohydrate-based spiro bis(isoxazolines): synthesis and evaluation in asymmetric catalysis
  作者：David Goyard、Susanne M. Telligmann、Catherine Goux-Henry、Mike M.K. Boysen、Eric Framery、David Gueyrard、Sébastien Vidal

  DOI：10.1016/j.tetlet.2009.11.028

  日期：2010.1

  Two carbohydrate-based spiro bis(isoxazolines) were synthesized via 1,3-dipolar cycloaddition from peracetylated methylene exo-glucal and the corresponding bis(arylnitrile oxide). The bis(cycloadducts) were then evaluated as ligands for enantioselective catalytic reactions. The Pd-catalyzed Tsuji-Trost reaction between a malonate and an allylic acetate did not provide good results. The poor conversion observed can be attributed to the rearrangement of the ligand in the reaction mixture to afford the corresponding ring-opened isoxazole which has been characterized. Both ligands were also evaluated in Cu(I)-catalyzed asymmetric imine alkynylation and afforded the product in good yield and modest enantioselectivity. (C) 2009 Elsevier Ltd. All rights reserved.