4-Hydroxypyrazolopyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 4-Hydroxypyrazolopyridine
• 英文别名: 4-hydroxypyrazolo[4,3-b]pyridine
• 化学式: C₆H₅N₃O
• 分子量: 135.12
• InChiKey: DHXAHORHIDOVNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pyrazolo[3,4-B]Pyridine Compound, and Its Use as a Pde4 Inhibitor
  申请人：Christensen Siegfried Benjamin

  公开号：US20080255186A1

  公开（公告）日：2008-10-16

  The invention provides N-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-3-methyl-5-isoxazolecarboxamide or a salt thereof, such as the compound or a pharmaceutically acceptable salt thereof. The invention also provides the use of the compound or salt as an inhibitor of phosphodiesterase type IV (PDE4.

  该发明提供了N-[1,6-二乙基-4-(四氢-2H-吡喃-4-基氨基)-1H-吡唑并[3,4-b]吡啶-5-基]甲基}-3-甲基-5-异噁唑羧酰胺或其盐，例如该化合物或其医药上可接受的盐。该发明还提供了该化合物或盐作为磷酸二酯酶IV型（PDE4）抑制剂的用途。
• PYRAZOLO[3,4-B]PYRIDINE COMPOUND, AND ITS USE AS A PDE4 INHIBITOR
  申请人：GLAXO GROUP LIMITED

  公开号：EP1940836A1

  公开（公告）日：2008-07-09
• [EN] PYRAZOLO[3,4-B]PYRIDINE COMPOUND, AND ITS USE AS A PDE4 INHIBITOR<br/>[FR] COMPOSE DE PYRAZOLO[3,4-B]PYRIDINE ET UTILISATION EN TANT QU'INHIBITEUR DE PDE4
  申请人：GLAXO GROUP LTD

  公开号：WO2007036734A1

  公开（公告）日：2007-04-05

  [EN] The invention provides N-[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-3-methyl-5-isoxazolecarboxamide Formula (I): or a salt thereof, such as the compound or a pharmaceutically acceptable salt thereof. The invention also provides the use of the compound or salt as an inhibitor of phosphodiesterase type IV (PDE4) and/or for the treatment and/or prophylaxis of an inflammatory and/or allergic disease, especially an inflammatory and/or allergic skin disease such as atopic dermatitis, in a mammal such as a human. External topical administration, e.g. topical administration to the skin, of the compound or salt is preferred, and external-topical pharmaceutical compositions are provided
  [FR] L'invention concerne un composé de N-[1,6-diéthyl-4-(tétrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]méthyl}-3-méthyl-5-isoxazolecarboxamide représenté par la formule (I):ou un sel de ce composé, tel que le composé ou un sel pharmaceutiquement acceptable de ce composé. L'invention concerne également l'utilisation de ce composé ou sel utilisés comme inhibiteur de la phosphodiestérase de type IV (PDE4) et/ou pour le traitement et/ou la prophylaxie de maladies inflammatoires et/ou allergiques de la peau telles que la dermatite atopique chez u mammifère tel que l'homme. Ce composé ou ce sel doivent être administrés sur la peau de préférence de façon topique. L'invention concerne des compositions pharmaceutiques topiques externes.