N-seryl-leucine | 6665-16-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-seryl-leucine
• 英文别名: (+/-)-α-(2-Amino-3-hydroxy-propionylamino)-isocapronsaeure；N-Seryl-leucin；2-[(2-Azaniumyl-3-hydroxypropanoyl)amino]-4-methylpentanoate
• CAS: 6665-16-3；54743-89-4；76970-36-0
• 化学式: C₉H₁₈N₂O₄
• 分子量: 218.253
• InChiKey: NFDYGNFETJVMSE-UHFFFAOYSA-N

物化性质

• 熔点：
  222-228 °C
• 沸点：
  512.2±50.0 °C(Predicted)
• 密度：
  1.212±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-hydroxymethyl-6-(2-methylpropyl)-2,5-diketopiperazine 在 硫酸 作用下， 生成 N-seryl-leucine
  参考文献：
  名称：

  Abderhalden; Bahn, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1935, vol. 234, p. 181,183

  摘要：

  DOI：

文献信息

• DIPEPTIDE-CONTAINING COMPOSITION FOR ORAL ADMINISTRATION
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1941896A1

  公开（公告）日：2008-07-09

  The present invention provides a composition for oral administration, which comprises at least one kind of dipeptide represented by the formula:         X-Y (wherein X represents alanyl, glycyl, arginyl, seryl, α-aspartyl or α-glutamyl, and Y represents valine, leucine or isoleucine), with an object of providing a composition for oral administration which is excellent in nutrition, pharmacological effect and gustation and comprises at least one kind selected from valine, leucine and isoleucine, or providing a composition for oral administration which is excellent in processing characteristics such as solubility and tableting property and comprises at least one kind selected from valine, leucine and isoleucine.

  本发明提供了一种口服组合物，它包含至少一种由式表示的二肽： X-Y (其中 X 代表丙氨酰、甘氨酰、精氨酰、丝氨酰、α-天冬氨酰或α-谷氨酰，Y 代表缬氨酸、亮氨酸或异亮氨酸），其目的是提供一种营养、药效和口感俱佳的口服组合物，该组合物至少包含一种选自缬氨酸、亮氨酸和异亮氨酸的二肽、或提供一种口服组合物，该组合物在加工特性（如溶解性和压片性能）方面非常出色，并包含至少一种选自缬氨酸、亮氨酸和异亮氨酸的成分。
• Dipeptide-Comprising Composition for Oral Administration
  申请人：Sakai Yasushi

  公开号：US20080305151A1

  公开（公告）日：2008-12-11

  The present invention provides a composition for oral administration, which comprises at least one kind of dipeptide represented by the formula: X-Y (wherein X represents alanyl, glycyl, arginyl, seryl, α-aspartyl or α-glutamyl, and Y represents valine, leucine or isoleucine), with an object of providing a composition for oral administration which is excellent in nutrition, pharmacological effect and gustation and comprises at least one kind selected from valine, leucine and isoleucine, or providing a composition for oral administration which is excellent in processing characteristics such as solubility and tableting property and comprises at least one kind selected from valine, leucine and isoleucine.
• US7846902B2
  申请人：——

  公开号：US7846902B2

  公开（公告）日：2010-12-07
• [EN] (GANODERMA LUCIDIUM) IY009 WHICH PRODUCES PROTEOGLYCAN (G009) HAVING EFFECT OF ENHANCING ANTITUMOR IMMUNITY
  申请人：——

  公开号：WO1992010562A1

  公开（公告）日：1992-06-25

  [EN] A strain, Ganoderma lucidium, which produces a proteoglycan (G009) which has an effect of enhancing antitumor immunity and contains beta -glucose, alpha -glucose, galactose, alpha -mannose and fructose as the sugar components and glycine, leucine, alanine, histidine, arginine, valine, aspartic acid, threonine, isoleucine, serylleucine, glutamic acid, tyrosine, proline, phenylalanine and methionine as the protein components, said proteoglycan being separated from the culture medium of Genoderma lucidium.
  [FR] Souche Ganoderma lucidium produisant un protéoglycane (G009) qui présente l'effet d'améliorer l'immunité antitumorale et renferme, à titre de constituants sucrés, le glucose-beta, le glucose-alpha, le mannose-alpha, et le fuctose, et à titre de constituants protéiques, la glycine, la leucine, l'alanine, l'histidine, l'arginine, la valine, l'acide aspartique, la thréonine, l'isoleucine, la séryl-leucine, l'acide glutamique, la tyrosine, la proline, la phénylalanine et la méthionine, ledit protéoglycane étant séparé du milieu de culture de Ganoderma lucidium.