(9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl) 2,3-dihydroxy-2-phenylpropanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl) 2,3-dihydroxy-2-phenylpropanoate
• 化学式: C₁₇H₂₁NO₅
• 分子量: 319.4
• InChiKey: JEJREKXHLFEVHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  82.5
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Immunogenic Conjugates for Producing Immune Responses to Drugs of Abuse and Methods of Use
  申请人：Mizel Steven B.

  公开号：US20120171239A1

  公开（公告）日：2012-07-05

  The present invention is based, in part, on flagellin adjuvants that enhance immune responses directed against drugs of abuse. Provided are conjugates comprising a flagellin adjuvant covalently linked to a drug of abuse or an immunologically similar derivative thereof. Also provided are methods of making the conjugates of the invention and use thereof for administration to a subject, e.g., to produce an immune response in the subject against the drug of abuse, to prevent addiction to the drug of abuse in the subject, to reduce the effect of the drug of abuse in the subject, to reduce the level of the drug of abuse in the brain of the subject, and/or to reduce the addiction in the subject to the drug of abuse.

  本发明部分基于增强针对药物滥用的免疫反应的鞭毛蛋白佐剂。提供的是包括鞭毛蛋白佐剂的共轭物，其与药物滥用或其免疫学上类似的衍生物共价连接。同时提供了制备该发明中的共轭物的方法，并用于向受试者施用，例如，在受试者中产生针对药物滥用的免疫反应，预防受试者对药物滥用的成瘾，减轻受试者对药物滥用的影响，降低受试者大脑中药物滥用的水平，以及/或减轻受试者对药物滥用的成瘾。
• Method for facilitating dieting employing an ACE inhibitor
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0381074A2

  公开（公告）日：1990-08-08

  A method is provided for facilitating dieting by suppressing appetite or desire for foods and/or preventing or reducing anxiety associated with dieting by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or SQ 29,852, alone or in combination with a calcium channel blocker such as diltiazem or nifedipine, over a prolonged period of treatment.

  提供了一种通过抑制食欲或对食物的欲望和/或预防或减少与节食有关的焦虑来促进节食的方法，该方法通过单独或与地尔硫卓或硝苯地平等钙通道阻滞剂联合使用一种 ACE 抑制剂，如卡托普利、福辛普利、佐芬普利或 SQ 29 852，进行长期治疗。
• Use of a calcium channel blocker for preventing or treating anxiety
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0400665A2

  公开（公告）日：1990-12-05

  The use of a calcium channel blocker such as diltiazem or nifedipine for inhibiting onset of or treating anxiety over a prolonged period of treatment is provided.

  提供了使用地尔硫卓或硝苯地平等钙通道阻滞剂抑制焦虑症发病或治疗焦虑症的长期治疗方法。
• Optically active clausenamides, process of the preparation thereof, pharmaceutical composition containing the same and their medical use
  申请人：INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP1348696A1

  公开（公告）日：2003-10-01

  The present invention relates to some new optically active clausenamide derivatives, process of the preparation thereof, a pharmaceutical composition containing the same and their medical use, particularly their use in the respects of hypoxia protective, nootropic and neurodegenerative disease such as cerebral ischemia, Alzheimer disease and vascular dementia.

  本发明涉及一些新的光学活性克劳烯酰胺衍生物、其制备工艺、含有这些衍生物的药物组合物及其医疗用途，特别是它们在缺氧保护、神经营养和神经退行性疾病（如脑缺血、阿尔茨海默病和血管性痴呆）方面的用途。
• AN EXTRACT OF XANTHOCERAS SORBIFOLIA BUNGE AND EXTRACTION AND USES THEREOF
  申请人：Liu, Tony

  公开号：EP1980262A1

  公开（公告）日：2008-10-15

  The present invention discloses a kind of Shinyleaf yellowhom extract mainly consisting of Shinyleaf yellowhom total saponins, which accounts for more than 5 0% of the total weight of the dried Shinyleaf yellowhom extract. The present invention also provides a method for preparing the above extract, as well as its use in the treatment of the urinary incontinence and frequent micturition due to senile dementia or urinary bladder degradation, children enuresis, pediatric mental retardation, brain aging, middle-aged and senile dementia and Parkinson's syndrome. The pharmaceutical preparations of the present invention include injections, tablets, capsules, soft capsules, oral liquid, drop pills, etc.

  本发明公开了一种新利叶黄酮提取物，其主要成分为新利叶黄酮总皂苷，占干燥新利叶黄酮提取物总重量的5 0%以上。本发明还提供了上述提取物的制备方法，以及其在治疗老年性痴呆或膀胱退化引起的尿失禁、尿频、小儿遗尿症、小儿智力低下、脑老化、中老年痴呆症、帕金森综合症等方面的用途。本发明的药物制剂包括注射剂、片剂、胶囊剂、软胶囊、口服液、滴丸等。