1,3,4-trihydroxy-5-oxocyclohexane-1-carboxylic acid | 10236-66-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 1,3,4-trihydroxy-5-oxocyclohexane-1-carboxylic acid
• 英文别名: 5-Dehydrochininsaeure；5-Dehydro-chinasaeure；¹⁴C-5-Dehydro-chinasaeure；3-Dehydrochininsaeure
• CAS: 10236-66-5
• 化学式: C₇H₁₀O₆
• 分子量: 190.153
• InChiKey: WVMWZWGZRAXUBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• MEDICINAL PRODUCT, ANTICANCER AGENT, MEDICINAL INTERMEDIATE PRODUCT, AND METHOD FOR PRODUCING CYCLIC CARBOXYLIC ACID COMPOUND OR DERIVATIVE THEREOF
  申请人：Sumitomo Bakelite Co.Ltd.

  公开号：EP3842045A1

  公开（公告）日：2021-06-30

  The medicinal product of the present invention contains, as an active ingredient, at least one of a cyclic carboxylic acid compound derived from a plant-derived saccharide and a microorganism, and a derivative thereof. Further, it is preferable that the cyclic carboxylic acid compound is a compound represented by Formula (1).

  本发明的药剂产品中，作为活性成分的环羧酸化合物，至少含有一种从植物糖类和微生物中提取的环羧酸化合物及其衍生物。此外，环羧酸化合物最好是由式（1）表示的化合物。
• Antimicrobial compounds and compositions, and uses thereof
  申请人：Akeso Biomedical, Inc.

  公开号：US10327423B2

  公开（公告）日：2019-06-25

  A method of enhancing the growth of an animal is provided. The method includes causing the animal to ingest or absorb an effective amount of one or more Fe III complex compounds, including but not limited to Fe III complexes comprising ligands bound to the iron center selected from amino acids or α-hydroxy acids, o-hydroxy benzoic acids or pyridine-2-carboxylic acids, such as ferric quinate, ferric tyrosine, ferric DOPA and ferric phenylalanine. Compounds which are structural and/or functional variants, derivatives and/or analogs of the foregoing compounds, as further described herein are also disclosed. Methods for inhibiting, reducing, or preventing biofilm formation or buildup on a surface; the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments; disinfecting surfaces, potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, to anti-microbial agents are also provided.

  提供了一种促进动物生长的方法。该方法包括使动物摄入或吸收有效量的一种或多种铁Ⅲ络合物，包括但不限于铁Ⅲ络合物，该络合物包含与铁中心结合的配体，这些配体选自氨基酸或α-羟基酸、邻羟基苯甲酸或吡啶-2-羧酸，例如奎宁酸铁、酪氨酸铁、DOPA铁和苯丙氨酸铁。本文还公开了前述化合物的结构和/或功能变体、衍生物和/或类似物。本发明还提供了抑制、减少或防止表面生物膜形成或堆积的方法；在生物和非生物环境中治疗、抑制细菌生长和抑制细菌定植的方法；消毒表面、增强抗生素和其他抗微生物剂的效果以及提高细菌和其他微生物对抗微生物剂的敏感性的方法。
• Process of obtaining type II dehydroquinase enzyme inhibitors and precursors thereof
  申请人：Gonzalez Bello Concepcion

  公开号：US20070185214A1

  公开（公告）日：2007-08-09

  The present invention relates to a process of obtaining type II dehydroquinase enzyme inhibitors and the precursors thereof from (−)-quinic acid. The described compounds have a carboxycyclohexene structure. The process of preparing the compounds and their application as compositions with pharmacological properties and herbicides of interest are described.
• ANTIMICROBIAL COMPOUNDS AND COMPOSITIONS, AND USES THEREOF
  申请人：Akeso Biomedical, Inc.

  公开号：US20160066578A1

  公开（公告）日：2016-03-10

  A method of enhancing the growth of an animal is provided. The method includes causing the animal to ingest or absorb an effective amount of one or more Fe III complex compounds, including but not limited to Fe III complexes comprising ligands bound to the iron centre selected from amino acids or α-hydroxy acids, o-hydroxy benzoic acids or pyridine-2-carboxylic acids, such as ferric quinate, ferric tyrosine, ferric DOPA and ferric phenylalanine. Compounds which are structural and/or functional variants, derivatives and/or analogs of the foregoing compounds, as further described herein are also disclosed. Methods for inhibiting, reducing, or preventing biofilm formation or buildup on a surface; the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments; disinfecting surfaces, potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, to anti-microbial agents are also provided.
• WATER-SOLUBLE ADDITIVE COMPOSITION
  申请人：SUMITOMO BAKELITE CO., LTD.

  公开号：US20220175000A1

  公开（公告）日：2022-06-09

  There is provided a water-soluble additive composition including a cyclic carboxylic acid, the water-soluble additive composition satisfying at least one of the following Conditions 1 to 4: (Condition 1) component (A) the cyclic carboxylic acid, which is other than the following component (B1), and component (B1) one or more selected from the group consisting of gallic acid and an ester thereof are included; (Condition 2) the total content of Na+ and NH4+ is equal to or more than 100 ppm and equal to or less than 5000 ppm with respect to the cyclic carboxylic acid; (Condition 3) the total inorganic ion content (excluding hydrogen ions and hydroxyl group ions) is equal to or more than 300 ppm and equal to or less than 5000 ppm with respect to the cyclic carboxylic acid; and (Condition 4) component (A) the cyclic carboxylic acid, which is other than the following component (B2), and component (B2) an amino acid are included.