2-carboxy-2,3-dihydro-5,6-dihydroxyindole | 25312-42-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-carboxy-2,3-dihydro-5,6-dihydroxyindole
• 英文别名: 5,6-dihydroxyindoline-2-carboxylic acid；dopachrome；5,6-Dihydroxy-2,3-dihydro-indol-2-carbonsaeure, Leukadopachrom；5,6-Dihydroxyindolin-2-carbonsaeure；5,6-dihydroxy-2,3-dihydro-indole-2-carboxylic acid；5,6-dihydroxy-2-carboxyindoline；Cyclodopa；2-carboxy-5-hydroxy-2,3-dihydro-1H-indol-1-ium-6-olate
• CAS: 25312-42-9
• 化学式: C₉H₉NO₄
• 分子量: 195.175
• InChiKey: JDWYRSDDJVCWPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  89.8
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES
  申请人：Henkel AG & Co. KGaA

  公开号：US20150209258A1

  公开（公告）日：2015-07-30

  The present application relates to agents for dyeing keratin fibers, in particular human hair, the agent including a cosmetic carrier and at least a compound of formula (I)

  本申请涉及染色角蛋白纤维的药剂，特别是人类头发，该药剂包括化妆品载体和至少一种符合式(I)的化合物。
• Inhibitors of hepatitis C virus NS3 protease
  申请人：——

  公开号：US20020065248A1

  公开（公告）日：2002-05-30

  The present invention relates to compounds of Formula (I): 1 wherein A 1 is methylene, ethylene or propylene group and A 2 is N or CR 5 , or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HCV NS3 protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

  本发明涉及化合物的结构公式（I）：其中A1为亚甲基、乙烯基或丙烯基，A2为N或CR5，或其立体异构体形式、立体异构体混合物或药用盐形式，用作HCV NS3蛋白酶的抑制剂，以及包含相同化合物的药物组合物和诊断试剂盒，以及用于治疗病毒感染或作为测定标准或试剂的方法。
• SUBSTITUTED P-PHENYLENEDIAMINES AS NEW OXIDATION DYE PRECURSOR PRODUCTS OF THE DEVELOPER TYPE
  申请人：Henkel AG & Co. KGaA

  公开号：US20170165166A1

  公开（公告）日：2017-06-15

  Compounds, and agents for oxidatively changing the color of keratinic fibers that include such compounds, in particular human hair, in a cosmetic carrier. The compounds are at least one oxidation dye precursor product of formula (I) and/or physiologically acceptable salt thereof, in which R1, R2, R3, R4 independently of one another, stand for a hydrogen atom, a C 1 -C 6 alkyl group, a C 2 -C 6 alkenyl group, a hydroxy-(C 1 -C 6 )-alkyl group, a polyhydroxy-(C 2 -C 6 )-alkyl group, or a C 1 -C 6 -alkoxy-C 2 -C 6 -alkyl group, n stands for an integer from 2 to 6, and Z stands for an aromatic or aliphatic heterocycle or for an aromatic or aliphatic carbocycle.

  这段文字的中文翻译如下： 化合物和氧化性改变角蛋白纤维颜色的药剂，包括这些化合物，特别是人类头发，在化妆品载体中。这些化合物至少是一种化学式(I)的氧化染料前体产品和/或其生理上可接受的盐，其中R1、R2、R3、R4分别独立地代表氢原子、C1-C6烷基、C2-C6烯基、羟基-(C1-C6)-烷基、多羟基-(C2-C6)-烷基或C1-C6-烷氧基-C2-C6-烷基，n代表一个从2到6的整数，Z代表芳香或脂肪杂环或芳香或脂肪碳环。
• SUBSTANCES FOR DYEING KERATINOUS FIBERS
  申请人：Gross Wibke

  公开号：US20100037909A1

  公开（公告）日：2010-02-18

  Disclosed are substances which contain unsaturated, non-aromatic dialdehydes of formula (Ia) and/or the tautomer (Ib) thereof, wherein R 1 , R 2 , and R 3 are defined as indicated in claim 1 , along with at least one CH-acidic compound of formulas (II) and/or (III), wherein R 6 , R 7 , R 8 , R 9 , R 10 , Y, X − , Het, and X 1 are defined as indicated in claim 1 , in a cosmetic carrier. Said substances color keratinous fibers, especially human hair, in an intensive, colorfast, natural brown shade.

  本发明涉及一种含有式(Ia)和/或其互变异构体(Ib)的不饱和非芳香二醛的物质，其中R1、R2和R3如权利要求1所示定义，以及至少一种式(II)和/或(III)的CH-酸性化合物，其中R6、R7、R8、R9、R10、Y、X−、Het和X1如权利要求1所示定义，在一种化妆品载体中。所述物质能够使角质纤维，尤其是人类头发，在一种浓郁、色牢、自然棕色的色调中着色。
• AGENT FOR DYEING KERATIN-CONTAINING FIBERS
  申请人：Gross Wibke

  公开号：US20100064450A1

  公开（公告）日：2010-03-18

  The invention relates to an agent for dying fibers comprising keratin, particularly human hair, the agent comprising at least one compound of the formula: together with at least one CH-acidic compound. The invention also relates to methods for shading oxidation dyed fibers, methods for freshening up fibers, methods for making an agent for dyeing fibers and to various compositions.

  该发明涉及一种用于染色纤维的药剂，包括角蛋白，特别是人类头发，该药剂包括至少一种具有以下结构的化合物：以及至少一种CH-酸性化合物。该发明还涉及用于给氧化染色纤维着色的方法，用于使纤维焕发的方法，用于制备染色纤维药剂的方法以及各种组合物。