acremonone A | 1373318-41-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: acremonone A
• 英文别名: 6,8-dimethoxy-9-methyl-2,3-dimethylidene-1,4-benzodioxepin-5-one
• CAS: 1373318-41-2
• 化学式: C₁₄H₁₄O₅
• 分子量: 262.262
• InChiKey: KUBDLSAHQDHTEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  acremonone A 在 palladium on activated charcoal 、 氢气 作用下， 生成
  参考文献：
  名称：

  Phthalide and Isocoumarin Derivatives Produced by an Acremonium sp. Isolated from a Mangrove Rhizophora apiculata

  摘要：

  Nine new fungal metabolites, one phthalide derivative, acremonide (1), and eight isocoumarin derivatives, acremonones A-H (2-9), were isolated from the mangrove-derived fungus Acremonium sp. PSU-MA70 together with 10 known compounds. Their structures were determined by NMR analysis. The known 8-deoxytrichothecin and tricho-dermol exhibited moderate antifungal activity against Candida albicans and Cryptococcus neoformanns, respectively.

  DOI：

  10.1021/np200885e

文献信息

• Phthalide and Isocoumarin Derivatives Produced by an <i>Acremonium</i> sp. Isolated from a Mangrove <i>Rhizophora apiculata</i>
  作者：Vatcharin Rukachaisirikul、Aekkachai Rodglin、Yaowapa Sukpondma、Souwalak Phongpaichit、Jirayu Buatong、Jariya Sakayaroj

  DOI：10.1021/np200885e

  日期：2012.5.25

  Nine new fungal metabolites, one phthalide derivative, acremonide (1), and eight isocoumarin derivatives, acremonones A-H (2-9), were isolated from the mangrove-derived fungus Acremonium sp. PSU-MA70 together with 10 known compounds. Their structures were determined by NMR analysis. The known 8-deoxytrichothecin and tricho-dermol exhibited moderate antifungal activity against Candida albicans and Cryptococcus neoformanns, respectively.