9-Oxooctadeca-10,12-dienoic acid | 54665-32-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9-Oxooctadeca-10,12-dienoic acid
• CAS: 54665-32-6
• 化学式: C₁₈H₃₀O₃
• 分子量: 294.4
• InChiKey: LUZSWWYKKLTDHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (Z,Z)-9,12-十八烷二烯酸二聚物 在 dipotassium hydrogenphosphate 、 lipoxygenase 、 氧气 、 potassium carbonate 、 磷酸 作用下， 以 水 为溶剂， 以3.7 %的产率得到13-oxo-9,11-octadecadienoic acid
  参考文献：
  名称：

  イネ科植物のための成長促進剤

  摘要：

  【課題】イネ科植物のための成長促進剤を提供することを目的とする。【解決手段】オキソ脂肪酸またはその誘導体もしくはその塩から選ばれる少なくとも１種の化合物を含むことを特徴とするイネ科植物のための成長促進剤。【選択図】なし

  公开号：

  JP2024091096A

文献信息

• Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof
  申请人：Board of Regents of the University of Texas System

  公开号：US10100317B2

  公开（公告）日：2018-10-16

  A method for treating and/or diagnosing pain and the source or type of pain, shock, and/or inflammatory conditions in a subject. A method of using a therapeutically effective amount of a DNA or RNA aptamer that shows high affinity for OLAMs to at least partially treat pain, shock, and/or inflammatory conditions in a subject. The DNA or RNA aptamer that shows high affinity for OLAMs may be coupled to a plasma protein binding compound or a pharmacologically active agent. A method of treating and or diagnosing pain, shock, and/or inflammatory conditions in a subject may include inactivating or preventing at least one linoleic acid metabolite to treat certain conditions (e.g., pain, shock, and/or inflammation) using a DNA or RNA aptamer that shows high affinity for OLAMs.

  一种治疗和/或诊断受试者疼痛以及疼痛、休克和/或炎症的来源或类型的方法。一种使用对 OLAMs 具有高亲和力的治疗有效量的 DNA 或 RNA 合体来至少部分治疗受试者的疼痛、休克和/或炎症的方法。对 OLAMs 具有高亲和力的 DNA 或 RNA 合体可与血浆蛋白结合化合物或药理活性剂偶联。治疗和或诊断受试者疼痛、休克和/或炎症的方法可包括使用对 OLAMs 表现出高亲和力的 DNA 或 RNA 合酶灭活或阻止至少一种亚油酸代谢物，以治疗某些病症（如疼痛、休克和/或炎症）。
• A NEW FAMILY OF PAIN PRODUCING SUBSTANCES AND METHODS TO PRODUCE NOVEL ANALGESIC DRUGS
  申请人：Board of Regents, The University of Texas System

  公开号：EP2381940A2

  公开（公告）日：2011-11-02
• A METHOD TO IMPROVE PHARMACOKINETICS OF DRUGS
  申请人：Board of Regents, The University of Texas System

  公开号：EP2908849B1

  公开（公告）日：2019-04-17
• Ascorbic acid conjugates
  申请人：Stevens Jan Frederik

  公开号：US20090104705A1

  公开（公告）日：2009-04-23

  Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F 2 -isoprostanes and malondialdehyde, to monitoring the redox status of glutathione. While useful, traditional biomarkers of oxidative stress are not without their drawbacks, including low in vitro concentrations and possible artifact formation. Disclosed herein are new marker compounds, including ascorbylated 4-hydroxy-2-nonenal, that are useful as biomarkers of oxidative stress.
• FAMILY OF PAIN PRODUCING SUBSTANCES AND METHODS TO PRODUCE NOVEL ANALGESIC DRUGS
  申请人：Patwardhan Amol Madhusudan

  公开号：US20110311545A1

  公开（公告）日：2011-12-22

  A method may include treating pain, shock, and/or inflammatory conditions in a subject. A method may include using a therapeutically effective amount of an antibody, a lipoxygenase inhibitor, a cytochrome P-450 enzyme inhibitor, and/or an antioxidant configurable to at least partially treat pain, shock, and/or inflammatory conditions in a subject. A method of treating pain, shock, and/or inflammatory conditions in a subject may include inactivating or preventing at least one linoleic acid metabolite to treat certain conditions (e.g., pain, shock, and/or inflammation).