γ,δ-Dihydroxy-leucin | 105817-05-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: γ,δ-Dihydroxy-leucin
• 英文别名: δ-Hydroxy-leuceninhydrat；γ.δ-Dihydroxy-leucin; α-Amino-γ.δ-dihydroxy-isocapronsaeure；2-Amino-4,5-dihydroxy-4-methylpentanoic acid；2-amino-4,5-dihydroxy-4-methylpentanoic acid
• CAS: 105817-05-8
• 化学式: C₆H₁₃NO₄
• 分子量: 163.174
• InChiKey: ASHXMQKUZGLXMR-UHFFFAOYSA-N

物化性质

• 沸点：
  428.8±45.0 °C(Predicted)
• 密度：
  1.345±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Preparation of phalloidin and its derivatives
  申请人：Liu Baosheng

  公开号：US20120214968A1

  公开（公告）日：2012-08-23

  The present invention relates to novel phalloidin derivatives and their fluorescent dye conjugates. These new compounds may be used in studies of actin dynamics in living systems. The present invention also relates to methods for preparing such compounds. The synthesis routes combine solid-phase and solution phase peptide synthesis, and has great advantage for efficient preparation of a diverse library of the phalloidin derivatives, especially for the synthesis of phalloidin.

  本发明涉及新型鬼笔环酯衍生物及其荧光染料偶联物。这些新化合物可用于研究活体系统中的肌动蛋白动力学。本发明还涉及制备这类化合物的方法。合成路线结合了固相和溶液相肽合成，对于高效制备多样化的鬼笔环酯衍生物文库具有巨大优势，尤其适用于鬼笔环酯的合成。
• US8569452B2
  申请人：——

  公开号：US8569452B2

  公开（公告）日：2013-10-29
• [EN] AMATOXIN ANALOGS AND USES THEREOF<br/>[FR] ANALOGUES D'AMATOXINE ET LEURS UTILISATIONS
  申请人：[en]THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：WO2022120476A1

  公开（公告）日：2022-06-16

  This application relates to amatoxin analogs in which the trans-4-substituent on the proline residue of the amatoxin is an R group other than a hydroxy, constructs comprising such amatoxin analogs coupled to a linker and conjugates comprising such amatoxin analog-linker constructs conjugated to a target moiety. The application also relates to uses of such amatoxin analogs, for example, in treatment of cancer. The analog is a compound of Formula I, wherein R1 is not OH: